Microglia are central nervous system (CNS) resident immune cells for which the impact of
MHC class I antigen presentation is still being defined. To directly address if microglia …

CD8 T cell responses are essential for clearance of infections in the CNS but contribute to
neuropathology. T cell interaction with antigen presenting cells (APCs) at CNS barriers is …

CD8 T cell infiltration of the central nervous system (CNS) is necessary for host protection
but contributes to neuropathology. Antigen presenting cells (APCs) situated at CNS borders …

The contribution of antigen-presenting cell (APC) types in generating CD8+ T cell responses
in the central nervous system (CNS) is not fully defined, limiting the development of vaccines …

Microglia are resident immune cells in the CNS, strategically positioned to clear dead cells
and debris, and orchestrate CNS inflammation and immune defense. In steady state, these …

There are numerous observations reporting that phagocytes expressing major
histocompatibility complex (MHC) Class II molecules are associated with the central nervous …

The central nervous system (CNS) is considered to be immune privileged, owing in part to
the absence of major histocompatibility (MHC) class II+ cells in the healthy brain …

The brain's immune privilege has been also attributed to the lack of dendritic cells (DC)
within its parenchyma and the adjacent meninges, an assumption, which implies …

The major histocompatibility complex (MHC) class II molecules play a critical role in
induction of immune responses through presentation of processed antigens to CD4+ helper …

Although mechanisms leading to brain-specific inflammation and T cell activation have been
widely investigated, regulatory mechanisms of local innate immune cells in the brain are …