Individualized Approach to Management of Light Chain Amyloidosis

G Palladini, P Milani - Journal of the National Comprehensive Cancer …, 2023 - jnccn.org
Systemic light chain (AL) amyloidosis is caused by a B-cell (most commonly plasma cell)
clone that produces a toxic light chain that forms amyloid fibrils in tissues and causes …

How I treat AL amyloidosis

G Palladini, G Merlini - Blood, The Journal of the American …, 2022 - ashpublications.org
The treatment of patients with systemic light chain (AL) amyloidosis is a challenge to
hematologists. Despite its generally small size, the underlying clone causes a rapidly …

Treatment options for relapsed/refractory systemic light-chain (AL) amyloidosis: current perspectives

S Sarosiek, V Sanchorawala - Journal of Blood Medicine, 2019 - Taylor & Francis
Systemic immunoglobulin light chain (AL) amyloidosis is a disorder characterized by the
production of clonal serum free light chains that misfold, aggregate, and deposit in vital …

[HTML][HTML] Light chain (AL) amyloidosis: update on diagnosis and management

M Rosenzweig, H Landau - Journal of Hematology & Oncology, 2011 - Springer
Light chain (AL) amyloidosis is a plasma cell dyscrasia characterized by the pathologic
production of fibrillar proteins comprised of monoclonal light chains which deposit in tissues …

Clinical trials evaluating potential therapies for light chain (AL) amyloidosis

E Muchtar, MA Gertz - Expert opinion on orphan drugs, 2017 - Taylor & Francis
Introduction: The field of systemic amyloidosis is experiencing major advances in diagnostic
and prognostic methods coupled with a growing availability in treatment options. Areas …

Updates in the diagnosis and management of AL amyloidosis

J Cook, E Muchtar, R Warsame - Current Hematologic Malignancy Reports, 2020 - Springer
Abstract Purpose of Review Light chain (AL) amyloidosis is an insidious progressive
disease which results in significant morbidity and inevitable mortality if not diagnosed and …

Prognosis and staging of AL amyloidosis

T Dittrich, C Kimmich, U Hegenbart… - Acta haematologica, 2020 - karger.com
The treatment options for systemic light chain amyloidosis (AL) are currently widening in an
unprecedented way, brought about by an expanding arsenal of anti-myeloma therapy as …

Presentation and outcome with second-line treatment in AL amyloidosis previously sensitive to nontransplant therapies

G Palladini, P Milani, A Foli, M Basset… - Blood, The Journal …, 2018 - ashpublications.org
The management of light chain (AL) amyloidosis has improved in recent years thanks to
accurate biomarker-based staging systems and response criteria and availability of novel …

[HTML][HTML] Recent advances in understanding and treating immunoglobulin light chain amyloidosis

T Badar, A D'Souza, P Hari - F1000Research, 2018 - ncbi.nlm.nih.gov
Immunoglobulin (Ig) light chain (AL) amyloidosis is a clonal plasma cell disorder
characterized by misfolded Ig light chain deposition in vital organs of the body, resulting in …

What is new in diagnosis and management of light chain amyloidosis?

G Palladini, G Merlini - Blood, The Journal of the American …, 2016 - ashpublications.org
Light chain (AL) amyloidosis is caused by a usually small plasma cell clone producing a
misfolded light chain that deposits in tissues. Survival is mostly determined by the severity of …