Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM),
leading to destruction of normal kidney architecture and loss of renal function. The activation …

Fibrosis is the common end point of chronic kidney disease. The persistent production of
inflammatory cytokines and growth factors leads to an ongoing process of extracellular …

Renal fibrosis is a common characteristic of chronic kidney disease (CKD). Aberrant and
excessive depositions of extracellular matrix (ECM) proteins in both glomeruli and interstitial …

Fibrosis is a characteristic feature of all forms of chronic kidney disease. Deposition of
pathological matrix in the interstitial space and within the walls of glomerular capillaries as …

Obstructive nephropathy is a major cause of renal failure, particularly in newborn babies and
children. After urinary tract obstruction, and under the influence of mechanical forces and …

Myofibroblast activation is a key event playing a critical role in the progression of chronic
renal disease. Emerging evidence suggests that myofibroblasts can derive from tubular …

Renal fibrosis is a major hallmark of chronic kidney disease that is considered to be a
common end point of various types of renal disease. To date, the biological meaning of …

Myofibroblasts play an important role in many tissue injuries, and particularly in renal
disease. The myofibroblast differentiation is an early event in the development of fibrosis …

Understanding the origin of myofibroblasts in kidney is of great interest because these cells
are responsible for scar formation in fibrotic kidney disease. Recent studies suggest …

Chronic kidney diseases (CKD), independent of their primary cause, lead to progressive,
irreversible loss of functional renal parenchyma. Renal pathology in CKD is characterized by …