The tumor micro-environment (TME) of hepatocellular carcinoma (HCC) consists out of
cirrhotic liver tissue and is characterized by an extensive deposition of extracellular matrix …

Liver fibrosis is a reversible pathology characterized by the up-regulated secretion and
deposition of ECM proteins and inhibitors of metalloproteinases, which increase the stiffness …

There is increasing evidence that the physical environment is a critical mediator of tumor
behavior. Hepatocellular carcinoma (HCC) develops within an altered biomechanical …

Liver fibrosis is characterized by the progressive accumulation of extracellular matrix (ECM)
and is a strong predictor of hepatocellular carcinoma (HCC) development and progression …

Tumor initiation and progression are critically dependent on interaction of cancer cells with
their cellular and extracellular microenvironment. Alterations in the composition, integrity …

The extracellular matrix (ECM) regulates cellular function through the dynamic
biomechanical and biochemical interplay between the resident cells and their …

Simple Summary The tumour microenvironment comprise cellular and non-cellular
components and is a dedicive factor in determining anti-cancer treatment efficiency. The …

Hepatic fibrosis progress accompanied by an unbalanced extracellular matrix (ECM)
degradation and deposition leads to an increased tissue stiffness. Hepatocytes interplay …

Epithelial-to-mesenchymal transition (EMT) is a complex process involving multiple genes,
steps and stages. It refers to the disruption of tight intercellular junctions among epithelial …

Hepatocellular carcinoma (HCC) and hepatic metastases of colon cancers are malignant
conditions of the liver that cause significant morbidity and mortality worldwide. Experimental …