[HTML][HTML] The hexosamine biosynthetic pathway as a therapeutic target after cartilage trauma: modification of chondrocyte survival and metabolism by glucosamine …
The hexosamine biosynthetic pathway (HBP) is essential for the production of uridine
diphosphate N-acetylglucosamine (UDP-GlcNAc), the building block of glycosaminoglycans …
diphosphate N-acetylglucosamine (UDP-GlcNAc), the building block of glycosaminoglycans …
Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes
M IGARAShI, I Kaga, Y TAkAMORI… - International …, 2011 - spandidos-publications.com
Glucosamine (GlcN) has been widely used to treat osteoarthritis (OA) in humans. However,
its chondroprotective action on the joint is poorly understood. In this study, to elucidate the …
its chondroprotective action on the joint is poorly understood. In this study, to elucidate the …
[HTML][HTML] Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants
EJ Uitterlinden, H Jahr, JLM Koevoet… - Osteoarthritis and …, 2006 - Elsevier
OBJECTIVE: To investigate the effect of glucosamine (GlcN) in a human osteoarthritic
explant model on expression of genes involved in anabolic and catabolic activities of …
explant model on expression of genes involved in anabolic and catabolic activities of …
[HTML][HTML] Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation
A Derfoul, AD Miyoshi, DE Freeman, RS Tuan - Osteoarthritis and Cartilage, 2007 - Elsevier
OBJECTIVES: Glucosamine (GlcN), a natural amino monosaccharide, is a constituent of
glycosaminoglycans (GAGs) found in hyaline cartilage. GlcN salts constitute a new class of …
glycosaminoglycans (GAGs) found in hyaline cartilage. GlcN salts constitute a new class of …
[HTML][HTML] Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression
S Varghese, P Theprungsirikul, S Sahani… - Osteoarthritis and …, 2007 - Elsevier
OBJECTIVE: To investigate the effects of glucosamine (GlcN) on chondrocyte proliferation,
matrix production, and gene expression for providing insights into the biochemical basis of …
matrix production, and gene expression for providing insights into the biochemical basis of …
Effect of glucosamine, a therapeutic agent for osteoarthritis, on osteoblastic cell differentiation
M Igarashi, K Sakamoto… - … Journal of Molecular …, 2011 - spandidos-publications.com
Osteoarthritis (OA) is characterized by qualitative and quantitative changes in the
architecture and composition of all the joint structures. Glucosamine (GlcN) has been used …
architecture and composition of all the joint structures. Glucosamine (GlcN) has been used …
Recent aspects of the chondroprotective and anti-inflammatory actions of glucosamine, a functional food
I NAGAOKA - Juntendo Medical Journal, 2014 - jstage.jst.go.jp
Glucosamine, a naturally occurring amino monosaccharide, is present in the connective and
cartilage tissues as a component of glycosaminoglycans. Thus, glucosamine has been …
cartilage tissues as a component of glycosaminoglycans. Thus, glucosamine has been …
[HTML][HTML] Effects of glucosamine sulfate on intracellular UDP-hexosamine and UDP-glucuronic acid levels in bovine primary chondrocytes
CJ Qu, M Jauhiainen, S Auriola, HJ Helminen… - Osteoarthritis and …, 2007 - Elsevier
OBJECTIVE: To analyze the effects of exogenously added glucose (Glc), glucosamine
(GlcN) and glucosamine sulfate (GS) on the intracellular UDP-hexoses (UDP-Hex), UDP-N …
(GlcN) and glucosamine sulfate (GS) on the intracellular UDP-hexoses (UDP-Hex), UDP-N …
Biological activities of glucosamine and its related substances
I Nagaoka, M Igarashi, K Sakamoto - Advances in food and nutrition …, 2012 - Elsevier
Glucosamine (GlcN) has been widely used to treat osteoarthritis (OA) in humans. We
revealed that among GlcN-derivatives (GlcN and N-acetyl-d-glucosamine) and uronic acids …
revealed that among GlcN-derivatives (GlcN and N-acetyl-d-glucosamine) and uronic acids …
[HTML][HTML] Comparison of glucose derivatives effects on cartilage degradation
T Phitak, P Pothacharoen, P Kongtawelert - BMC Musculoskeletal …, 2010 - Springer
Abstract Background Glucosamine (GlcN) is a well-recognized candidate for treatment of
osteoarthritis. However, it is currently used in derivative forms, such as glucosamine …
osteoarthritis. However, it is currently used in derivative forms, such as glucosamine …