Serotonin receptors of type 6 (5-HT6): what can we expect from them?

D Marazziti, S Baroni… - Current medicinal …, 2011 - ingentaconnect.com
The serotonin (5-HT) receptors of type 6 (5-HT6) are relatively new. They are quite different
from all other 5-HT receptors, as they are characterized by a short third cytoplasmatic loop …

Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology

D Marazziti, S Baroni, F Borsini… - Current Medicinal …, 2013 - ingentaconnect.com
The serotonin (5-HT) receptors of type 6 (5-HT6) are quite different from all other 5-HT
receptors, as they include a short third cytoplasmatic loop and a long C-terminal tail, and …

Latest advances towards the discovery of 5-HT7 receptor ligands

V Pittala, D Pittala - Mini Reviews in Medicinal Chemistry, 2011 - ingentaconnect.com
The 5-HT7 receptor (5-HT7R), characterized in 1993, is the most recently described member
of the serotonin family. Since its discovery, 5-HT7R has been the subject of extensive …

5-HT7 receptor ligands: recent developments and potential therapeutic applications

V Pittala, L Salerno, M Modica… - Mini reviews in …, 2007 - ingentaconnect.com
The 5-HT7 receptors (5-HT7Rs) are the most recent classified members of the serotonin
family. Characterized in 1993, they belong to the G protein-coupled receptor family. Since …

Higher-End Serotonin Receptors:  5-HT5, 5-HT6, and 5-HT7

RA Glennon - Journal of medicinal chemistry, 2003 - ACS Publications
Serotonin (5-hydroxytryptamine, 5-HT; 1) is a major neurotransmitter that is believed to
produce many of its effects via interaction at seven populations of 5-HT receptors, 5-HT1 to 5 …

Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders

M Leopoldo, E Lacivita, F Berardi, R Perrone… - Pharmacology & …, 2011 - Elsevier
Since its discovery in the 1940s in serum, the mammalian intestinal mucosa, and in the
central nervous system, serotonin (5-HT) has been shown to be involved in virtually all …

Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review

SL Thirumaran, A Lepailleur, C Rochais - European Journal of Medicinal …, 2019 - Elsevier
HT 7 receptors are the most recently discovered serotonergic receptors, for which numerous
physiological implications in the central and the peripheral nervous systems as well as the …

Serotonin7 receptors (5-HT7Rs) and their ligands

M Leopoldo - Current medicinal chemistry, 2004 - ingentaconnect.com
Serotonin (5-HT) is involved in various physiological and pathological processes by
interaction with 14 distinct receptor subtypes, grouped in seven classes of receptors (5-HT 1 …

Pharmacology and Therapeutic Potential of the 5-HT7 Receptor

KM Blattner, DJ Canney, DA Pippin… - ACS Chemical …, 2018 - ACS Publications
It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a
series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first …

5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 – 2009)

M Leopoldo, E Lacivita, F Berardi… - Expert Opinion on …, 2010 - Taylor & Francis
Importance of the field: The 5-HT7 receptors are discretely localized within the CNS
(thalamus, hypothalamus, limbic and cortical regions). The 5-HT7 receptors are also present …