The 5-HT7 receptor and disorders of the nervous system: an overview

PB Hedlund - Psychopharmacology, 2009 - Springer
Rationale The 5-HT 7 receptor is a more recently discovered G-protein-coupled receptor for
serotonin. The functions and possible clinical relevance of this receptor are not yet fully …

5-HT1A Receptor: An Old Target as a New Attractive Tool in Drug Discovery from Central Nervous System to Cancer

F Fiorino, B Severino, E Magli, A Ciano… - Journal of Medicinal …, 2014 - ACS Publications
The serotonin receptor subtype 5-HT1A was one of the first serotonin receptor subtypes
pharmacologically characterized. This receptor subtype has long been object of intense …

Advances in the design of 5-HT6 receptor ligands with therapeutic potential

D Witty, M Ahmed, TT Chuang - Progress in medicinal chemistry, 2009 - Elsevier
Publisher Summary The serotonin (5-hydroxytryptamine, 5-HT) neurotransmitter system in
the brain plays a key role in a range of central functions including cognitive, motor, sensory …

Structure–Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update

MN Modica, E Lacivita, S Intagliata… - Journal of Medicinal …, 2018 - ACS Publications
Serotonin 5-HT7 receptor (5-HT7R) has been the subject of intense research efforts
because of its presence in brain areas such as the hippocampus, hypothalamus, and cortex …

Small molecule 5-HT6R ligands: a comprehensive insight into their selectivity and activity

AV Ivachtchenko, YA Ivanenkov - Current Bioactive …, 2013 - ingentaconnect.com
In recent years, considerable research efforts have focused on the role of serotonin in
various pathological states, as well as on the identification of the respective serotonin …

Emerging opportunities and concerns for drug discovery at serotonin 5-5-ht2b receptors

J Brea, J Castro-Palomino, S Yeste… - Current topics in …, 2010 - ingentaconnect.com
5-HT2B receptors have been reported to play an important role at cardiac, intestinal and
central levels, as well as in bone marrow formation and growth. In the last decade, 5-HT2B …

Partial agonist efficacy of EMD386088, a 5-HT6 receptor ligand, in functional in vitro assays

M Jastrzębska-Więsek, A Siwek, G Kazek… - Pharmacological …, 2013 - Elsevier
Background Over recent years, the 5-hydroxytryptamine 6 (5-HT 6) receptor has emerged as
a promising molecular target which interacts with several central nervous system acting …

Differential agonist-mediated internalization of the human 5-hydroxytryptamine 7 receptor isoforms

CR Guthrie, AT Murray, AA Franklin… - Journal of Pharmacology …, 2005 - ASPET
The human 5-hydroxytryptamine 7 (5-HT7) serotonin receptor is a class A G-protein coupled
receptor that has three isoforms, 5-HT7 (a), 5-HT7 (b), and 5-HT7 (d), which are produced by …

Serotonin 5-HT3 and 5-HT4 ligands: an update of medicinal chemistry research in the last few years

MN Modica, V Pittala, G Romeo… - Current medicinal …, 2010 - ingentaconnect.com
The biogenic amine serotonin (5-hydroxytryptamine, 5-HT) is one of the most studied
neurotransmitters in the central nervous system. It acts through the activation of at least …

Serotonergic 5-HT6 receptor antagonists: heterocyclic chemistry and potential therapeutic significance

A Bali, S Singh - Current Topics in Medicinal Chemistry, 2015 - ingentaconnect.com
The serotonin 5-HT6 receptor (5-HT6R) is amongst the recently discovered serotonergic
receptors with almost exclusive localization in the brain. Hence, this receptor is fast …