Incorporation of adequate clearance methodologies for viral safety assurance constitutes an
integral part of the manufacturing process for plasma-derived biologicals. Filtration, being …

Tangentialâ•’Flow Filtration for Virus Capture Page 1 &CHAPTER 20 Tangential-Flow Filtration for
Virus Capture S. RANIL WICKRAMASINGHE Department of Chemical and Biological …

Advances in membrane technology have allowed the expansion of the size-exclusion
removal principle to viruses of concern in the processing of pharmaceutical drug products …

To protect against virus infections, the new technology of the virus removal membrane has
been developed. The novel virus removal filter PLANOVA is validated for virus removal, that …

Virus removal by a novel filter (Ultipor VF DV50), comprising three layers of PVDF
membrane, has been evaluated by infectivity studies using a range of viruses and …

Untreated membrane filters retain viruses by adsorption, as well as by physical restriction
which occurs when the pore diameter of the filter is smaller than that of the virus particle. As …

Commercial bioreactors employing mammalian cell cultures to express biological or
pharmaceutical products can become contaminated with adventitious viruses. The high …

Viral agents (influenza A virus, 80—120 nm; phage T1, 50 nm head, 150 nm head, 150 nm
tail; phage PR772, 53 nm; poliovirus, 28—30 nm; and phage PP7, 25 nm) were used to …

Ultrafiltration is frequently used in the biotechnology industry for protein purification. The
main applications of ultrafiltration are for protein concentration and buffer exchange. This …

The growing interest in process intensification and continuous processing has led to
concerns regarding the performance of virus removal filters at low permeate fluxes. This …