Determinants of eukaryal cell killing by the bacterial ribotoxin PrrC
B Meineke, B Schwer, R Schaffrath… - Nucleic acids …, 2011 - academic.oup.com
Abstract tRNA damage inflicted by the Escherichia coli anticodon nuclease PrrC (Eco PrrC)
underlies an antiviral response to phage T4 infection. PrrC homologs are present in many …
underlies an antiviral response to phage T4 infection. PrrC homologs are present in many …
[HTML][HTML] Structure–function relations in the NTPase domain of the antiviral tRNA ribotoxin Escherichia coli PrrC
B Meineke, S Shuman - Virology, 2012 - Elsevier
Breakage of tRNA by Escherichia coli anticodon nuclease PrrC (EcoPrrC) underlies a host
antiviral response to phage T4 infection. Expression of EcoPrrC is cytocidal in yeast …
antiviral response to phage T4 infection. Expression of EcoPrrC is cytocidal in yeast …
Determinants of the cytotoxicity of PrrC anticodon nuclease and its amelioration by tRNA repair
B Meineke, S Shuman - RNA, 2012 - rnajournal.cshlp.org
Breakage of tRNALys (UUU) by the Escherichia coli anticodon nuclease PrrC (Eco PrrC)
underlies a host antiviral response to phage T4 infection that is ultimately thwarted by a virus …
underlies a host antiviral response to phage T4 infection that is ultimately thwarted by a virus …
The t6A modification acts as a positive determinant for the anticodon nuclease PrrC, and is distinctively nonessential in Streptococcus mutans
JM Bacusmo, SS Orsini, J Hu, M DeMott… - RNA biology, 2018 - Taylor & Francis
Endoribonuclease toxins (ribotoxins) are produced by bacteria and fungi to respond to
stress, eliminate non-self competitor species, or interdict virus infection. PrrC is a bacterial …
stress, eliminate non-self competitor species, or interdict virus infection. PrrC is a bacterial …
[HTML][HTML] Dual nucleotide specificity determinants of an infection aborting anticodon nuclease
E Krutkina, D Klaiman, T Margalit… - Virology, 2016 - Elsevier
Abstract The anticodon nuclease (ACNase) PrrC is silenced by a DNA restriction-
modification (RM) protein and activated by a phage T4-encoded restriction inhibitor. The …
modification (RM) protein and activated by a phage T4-encoded restriction inhibitor. The …
The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiae
JC Chiou, XP Li, M Remacha… - Molecular …, 2008 - Wiley Online Library
Ribosome inactivating proteins (RIPs) like ricin, pokeweed antiviral protein (PAP) and Shiga‐
like toxins 1 and 2 (Stx1 and Stx2) share the same substrate, the α‐sarcin/ricin loop, but …
like toxins 1 and 2 (Stx1 and Stx2) share the same substrate, the α‐sarcin/ricin loop, but …
[PDF][PDF] RNA repair: an antidote to cytotoxic eukaryal RNA damage
J Nandakumar, B Schwer, R Schaffrath, S Shuman - Molecular cell, 2008 - cell.com
RNA healing and sealing enzymes drive informational and stress response pathways
entailing repair of programmed 2′, 3′ cyclic PO 4/5′-OH breaks. Fungal, plant, and …
entailing repair of programmed 2′, 3′ cyclic PO 4/5′-OH breaks. Fungal, plant, and …
An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs
ADP-ribosyltransferases (ARTs) were among the first identified bacterial virulence factors.
Canonical ART toxins are delivered into host cells where they modify essential proteins …
Canonical ART toxins are delivered into host cells where they modify essential proteins …
PrrC-anticodon nuclease: functional organization of a prototypical bacterial restriction RNase
S Blanga-Kanfi, M Amitsur, A Azem… - Nucleic acids …, 2006 - academic.oup.com
The tRNALys anticodon nuclease PrrC is associated in latent form with the type Ic DNA
restriction endonuclease EcoprrI and activated by a phage T4-encoded inhibitor of EcoprrI …
restriction endonuclease EcoprrI and activated by a phage T4-encoded inhibitor of EcoprrI …
A fungal anticodon nuclease ribotoxin exploits a secondary cleavage site to evade tRNA repair
B Meineke, A Kast, B Schwer, F Meinhardt, S Shuman… - RNa, 2012 - rnajournal.cshlp.org
PaOrf2 and γ-toxin subunits of Pichia acaciae toxin (PaT) and Kluyveromyces lactis zymocin
are tRNA anticodon nucleases. These secreted ribotoxins are assimilated by …
are tRNA anticodon nucleases. These secreted ribotoxins are assimilated by …