[HTML][HTML] Toxicogenomics analysis of dynamic dose-response in macrophages highlights molecular alterations relevant for multi-walled carbon nanotube-induced lung …

LA Saarimäki, PAS Kinaret, G Scala, G del Giudice… - NanoImpact, 2020 - Elsevier
Toxicogenomics approaches are increasingly used to gain mechanistic insight into the
toxicity of engineered nanomaterials (ENMs). These emerging technologies have been …

[HTML][HTML] Multi-walled carbon nanotubes elicit concordant changes in DNA methylation and gene expression following long-term pulmonary exposure in mice

G Scala, MN Delaval, SP Mukherjee, A Federico… - Carbon, 2021 - Elsevier
Pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) causes inflammation and
fibrosis. Our previous work has shown that industrially produced MWCNTs trigger specific …

Network Analysis Reveals Similar Transcriptomic Responses to Intrinsic Properties of Carbon Nanomaterials in Vitro and in Vivo

P Kinaret, V Marwah, V Fortino, M Ilves, H Wolff… - ACS …, 2017 - ACS Publications
Understanding the complex molecular alterations related to engineered nanomaterial (ENM)
exposure is essential for carrying out toxicity assessment. Current experimental paradigms …

[HTML][HTML] The in vitro immunomodulatory effect of multi-walled carbon nanotubes by multilayer analysis

V Hautanen, J Morikka, LA Saarimäki, J Bisenberger… - NanoImpact, 2023 - Elsevier
The study of multi-walled carbon nanotube (MWCNT) induced immunotoxicity is crucial for
determining hazards posed to human health. MWCNT exposure most commonly occurs via …

Multiwalled carbon nanotubes of varying size lead to DNA methylation changes that correspond to lung inflammation and injury in a mouse model

E Cole, JL Ray, S Bolten, RF Hamilton Jr… - Chemical Research …, 2019 - ACS Publications
Diversity in physicochemical properties of engineered multiwalled carbon nanotubes
(MWCNTs) increases the complexity involved in interpreting toxicity studies of these …

In vivo activation of a T helper 2-driven innate immune response in lung fibrosis induced by multi-walled carbon nanotubes

J Dong, Q Ma - Archives of toxicology, 2016 - Springer
Pulmonary exposure to certain forms of carbon nanotubes (CNT) induces fibrosing lesions
in the lungs that manifest an acute inflammation followed by chronic interstitial fibrosis. The …

Macrophage polarization and activation at the interface of multi-walled carbon nanotube-induced pulmonary inflammation and fibrosis

J Dong, Q Ma - Nanotoxicology, 2018 - Taylor & Francis
Pulmonary exposure to carbon nanotubes (CNTs) induces fibrosing lesions in the lungs that
manifest rapid-onset inflammatory and fibrotic responses, leading to chronic fibrosis in …

[HTML][HTML] Ranking of nanomaterial potency to induce pathway perturbations associated with lung responses

S Halappanavar, L Rahman, J Nikota, SS Poulsen… - NanoImpact, 2019 - Elsevier
Global transcriptomic responses in lungs of mice exposed for 24 h to individual multi-walled
carbon nanotubes (MWCNTs, ten different types), nano titanium dioxide (nano TiO 2, nine …

Single-walled vs. multi-walled carbon nanotubes: influence of physico-chemical properties on toxicogenomics responses in mouse lungs

SA Solorio-Rodriguez, A Williams, SS Poulsen… - Nanomaterials, 2023 - mdpi.com
Single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs)
are nanomaterials with one or multiple layers of carbon sheets. While it is suggested that …

[HTML][HTML] MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in …

SS Poulsen, AT Saber, A Williams, O Andersen… - Toxicology and applied …, 2015 - Elsevier
Multi-walled carbon nanotubes (MWCNTs) are an inhomogeneous group of nanomaterials
that vary in lengths, shapes and types of metal contamination, which makes hazard …