Hemolytic diseases are associated with elevated levels of circulating free heme that can
mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly …

Xanthine oxidoreductase (XOR) is a ubiquitous metalloflavoprotein that appears in two
interconvertible yet functionally distinct forms: xanthine dehydrogenase (XD), which is …

Xanthine oxidase (XO) is a critical source of reactive oxygen species (ROS) in inflammatory
disease. Focus, however, has centered almost exclusively on XO-derived superoxide …

Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from
a complicated evolutionary process that assigned it many physiological roles. The main …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that
exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

Cardiovascular diseases (CVD) are the leading cause of global mortality and their
pathogenesis lies mainly in the atherosclerotic process. There are close connections linking …

Background: Chronic kidney disease (CKD) is associated with increased cardiovascular
morbidity and mortality. Oxidative stress seems to play a pivotal role in this process, and …

Objective—We have previously demonstrated that endothelial xanthine oxidase (XO) levels
are dependent on the NADPH oxidase. We postulated that H2O2 may modulate the …