Nanomedicines suffer from poor drug loading and uncontrolled 'burst release'after
administration. Combining prodrug strategies with nanostructured carriers can help to …

Background: Lipid nanoparticles are considered one of the most promising systems for
controlled release of therapeutic molecules highly hydrophobic and with low biodisponibility …

Lipid nanoparticles have attracted significant interests in the last two decades, and have
achieved tremendous clinical success since the first clinical approval of Doxil in 1995. At the …

Abstract Lipid-drug conjugates (LDC), which may also be addressed as lipoidal prodrug,
have the therapeutic actives chemically bound to a lipid moiety like fatty acids or …

The discovery of new drug molecules depends on a number of steps, which limits the
development of feasible new drugs for the treatment of disease without any side effects …

Lipid-based drug-delivery systems have evolved from micro-to nano-scale, enhancing the
efficacy and therapeutic applications of these delivery systems. Production of lipid-based …

Liposomes are spherical-enclosed membrane vesicles mainly constructed with lipids. Lipid
nanoparticles are loaded with therapeutics and may not contain an enclosed bilayer. The …

Application of nanotechnology in the medical field (ie, nanomedicine) plays an important
role in the development of novel drug delivery methods. Nanoscale drug delivery systems …

Lipid-based nanomedicines are one of the oldest and the most successful nanotechnology-
based drug delivery systems. This success of lipid-based nanomedicines is attributed to …

Nanotechnology has made a great impact on the pharmaceutical, biotechnology, food, and
cosmetics industries. More than 40% of the approved drugs are lipophilic and have poor …