Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG
motifs within certain flanking base pairs are recognized as a danger signal by the innate …

Exposure to bacterial DNA generates a “danger signal” that stimulates cellular elements of
the mammalian immune system to proliferate and/or secrete cytokines. Stimulation is …

Oligodeoxynucleotides (ODNs) with unmethylated CpG dinucleotide motifs may be useful as
non-specific immune system stimulants and adjuvants for protein or nucleic acid vaccines in …

Bacterial DNA contains a much higher frequency of CpG dinucleotides than are present in
mammalian DNA. Furthermore, bacterial CpG dinucleotides are often not methylated. It is …

Cytosine-phosphate-guanosine (CpG)-DNA can induce an impressive array of innate
immune responses that may directly or indirectly contribute to the clearance of infectious …

Oligodeoxynucleotides (ODN) containing cytosine–phosphate–guanosine (CpG) motifs
have been shown to activate the innate immune system and protect mice and chicken from …

Bacterial DNA and synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG
motifs in particular sequence contexts (CpG ODN) are recognized as a danger signal by the …

Two CpG-oligodeoxynucleotide motifs, a mouse-specific one (CpGmouse) 5′-
GCTAGACGTTAGCGT-3′ and a porcine-specific one (CpGpig), 5′-TGCATCGATGCAG …

Examples exist in the literature that demonstrate that treatment with immunostimulatory
cytosine–phosphate–guanosine (CpG)‐DNA can protect mice against infection by …

Natural interferon‐producing cells (NIPC), also referred to as immature plasmacytoid
dendritic cells (PDC), constitute a small population of leucocytes secreting high levels of …