In recent decades, an enormous effort has been made to elucidate the pathogenesis of
autoimmune and autoinflammatory diseases. Autoimmunity is a multifactorial process in …

Complex autoimmune diseases are chronic conditions initiated by a loss of immunological
tolerance to self-antigens. Despite many years of intense investigation, the etiopathogenic …

Autoimmune diseases are the result of specific immune responses directed against
structures of the self (Burnet and Fenner, 1949). The organism possesses powerful …

The immune system specifically recognizes and eliminates foreign antigens and, thus,
protects integrity of the host. During maturation of the immune system, tolerance …

Autoimmunity refers to an organism's immune response against its own healthy cells,
tissues, or components, potentially leading to irreversible damage to vital organs. Central …

The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the
multifactorial origin and diversity of expression of autoimmune diseases in humans. The …

With the exception of an extremely small number of cases caused by single gene mutations,
most autoimmune diseases result from the complex interplay between environmental and …

The immune system specifically recognizes and eliminates foreign agents thereby protecting
the host against infection. During maturation of the immune system, immune cells that react …

Autoimmune diseases are common diseases in which loss of tolerance within the immune
system results in pathologic immune responses that target either cellular or organ-specific …

The rising incidence of autoimmune diseases is straining the healthcare system's capacity to
care for patients with autoimmunity. To further compound this growing crisis, this rise occurs …