Glucose homeostasis is critically dependent on insulin release from pancreatic β-cells,
which is strictly regulated by glucose-induced oscillations in membrane potential (Vm) and …

Insulin secretion in β-pancreatic cells due to glucose stimulation requires the coordinated
alteration of cellular ion concentrations and a substantial membrane depolarization to …

TRPM4 is a calcium-activated non-selective cation channel that is widely expressed and
proposed to be involved in cell depolarization. In excitable cells, TRPM4 may regulate …

TRPM4 is a Ca2+-activated non-selective cation (CAN) channel that functions in cell
depolarization, which is important for Ca2+ influx and insulin secretion in pancreatic β-cells …

OBJECTIVE TRPM2 is a Ca2+-permeable nonselective cation channel activated by
adenosine dinucleotides. We previously demonstrated that TRPM2 is activated by …

Abstract TRPM2 is a Ca 2+-permeable non-selective cation channel that can be activated by
adenosine dinucleotides, hydrogen peroxide, or intracellular Ca 2+. The protein is …

TRPM2 Ca2+-permeable cation channel is widely expressed and activated by markers of
cellular stress. Since inflammation and stress play a major role in insulin resistance, we …

There is now overwhelming evidence that TRP channels might play a significant role in the
regulation of insulin release from pancreatic β cells, which is until now insufficiently …

Transient receptor potential (TRP) proteins are a diverse family of proteins with structural
features typical of ion channels. TRPM5, a member of the TRPM subfamily, plays an …

Nonselective cation channels may play a role in insulin secretion by regulating pancreatic β-
cell plasma membrane potential, Ca2+ homeostasis, and thereby glucose signaling …