[HTML][HTML] Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats
C Cruciani-Guglielmacci, A Hervalet, L Douared… - Diabetologia, 2004 - Springer
Aims/hypothesis NEFA play a key role in the setting of insulin resistance and
hyperinsulinaemia, which are both features of the prediabetic state. In addition to the direct …
hyperinsulinaemia, which are both features of the prediabetic state. In addition to the direct …
[HTML][HTML] Influence of endogenous NEFA on beta cell function in humans
Aims/hypothesis It is a commonly held view that chronically elevated NEFA levels adversely
affect insulin secretion and insulin action (lipotoxicity). However, the effect of NEFA on beta …
affect insulin secretion and insulin action (lipotoxicity). However, the effect of NEFA on beta …
[HTML][HTML] Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 hours of moderate hyperglycaemia on insulin sensitivity and …
N Leung, T Sakaue, A Carpentier, K Uffelman… - Diabetologia, 2004 - Springer
Aims/hypothesis A prolonged increase of plasma NEFA impairs acute glucose-stimulated
insulin secretion (GSIS) in vitro and in vivo. Our study therefore examined the combined …
insulin secretion (GSIS) in vitro and in vivo. Our study therefore examined the combined …
Free fatty acid–induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo
AI Oprescu, G Bikopoulos, A Naassan, EM Allister… - Diabetes, 2007 - Am Diabetes Assoc
OBJECTIVE—An important mechanism in the pathogenesis of type 2 diabetes in obese
individuals is elevation of plasma free fatty acids (FFAs), which induce insulin resistance and …
individuals is elevation of plasma free fatty acids (FFAs), which induce insulin resistance and …
[HTML][HTML] Effects of insulin-induced hypoglycaemia on lipolysis rate, lipid oxidation and adipose tissue signalling in human volunteers: a randomised clinical study
TS Voss, MH Vendelbo, U Kampmann, SB Pedersen… - Diabetologia, 2017 - Springer
Aims/hypothesis The aims of this study were to determine the role of lipolysis in
hypoglycaemia and define the underlying intracellular mechanisms. Methods Nine healthy …
hypoglycaemia and define the underlying intracellular mechanisms. Methods Nine healthy …
Intracerebroventricular infusion of a triglyceride emulsion leads to both altered insulin secretion and hepatic glucose production in rats
L Clément, C Cruciani-Guglielmacci, C Magnan… - Pflügers Archiv, 2002 - Springer
We investigated here whether non-esterified fatty acids (NEFA) influence insulin secretion
and action through a direct effect on central nervous system sites involved in the control of …
and action through a direct effect on central nervous system sites involved in the control of …
Fatty acids and insulin secretion
V Grill, E Qvigstad - British Journal of Nutrition, 2000 - cambridge.org
It has long been recognized that acute elevation of non-esterified fatty acids (NEFA)
stimulates insulin secretion to a moderate extent both in vitro and in vivo. The effects of …
stimulates insulin secretion to a moderate extent both in vitro and in vivo. The effects of …
Opposite effects of short-and long-term fatty acid infusion on insulin secretion in healthy subjects
G Paolisso, A Gambardella, L Amato, R Tortoriello… - Diabetologia, 1995 - Springer
Our study investigates short-and long-term effects of infusion of non-esterified fatty acids
(NEFA) on insulin secretion in healthy subjects. Twelve healthy individuals underwent a 24 …
(NEFA) on insulin secretion in healthy subjects. Twelve healthy individuals underwent a 24 …
[HTML][HTML] Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver
P Iozzo, R Lautamaki, F Geisler, KA Virtanen… - Diabetologia, 2004 - Springer
Aims/hypothesis We investigated the effect of elevated circulating NEFA on insulin-mediated
hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male …
hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male …
[HTML][HTML] Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis
S Kehlenbrink, S Koppaka, M Martin, R Relwani… - Diabetologia, 2012 - Springer
Aims/hypothesis Acute hyperglycaemia rapidly suppresses endogenous glucose production
(EGP) in non-diabetic individuals, mainly by inhibiting glycogenolysis. Loss of this 'glucose …
(EGP) in non-diabetic individuals, mainly by inhibiting glycogenolysis. Loss of this 'glucose …