The role of mitochondria in the establishment of developmental competence for the
preimplantation mammalian embryo is an area of growing interest for researchers …

This review examines the place of mitochondria in the life cycle through oogenesis,
ovulation and early embryogenesis. Mitochondria are semi-autonomous organelles …

The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

Mitochondrial biology plays an important role in the reproductive process, with influence on
germ cell development and quality as well as embryonic development and reproductive …

The mitochondria of the oocyte are a prominent source of energy metabolism as well as
mitochondrial DNA that will later populate the cells of the offspring. Recent discoveries …

Genetic defects of the mitochondrial genome can be especially devastating to patients;
moreover, attention on human mitochondrial disorders has grown remarkably in recent …

Mitochondria are well known as 'the powerhouses of the cell'. Indeed, their major role is
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …

In addition to their role in generating energy (ATP), other possible regulatory functions for
mitochondria in the mature oocyte, preimplantation stage embryo and differentiating …

The oocyte requires a vast supply of energy after fertilization to support critical events such
as spindle formation, chromatid separation, and cell division. Until blastocyst implantation …

STUDY QUESTION Does mitochondrial deficiency affect human embryonic preimplantation
development? SUMMARY ANSWER The presence of a pathogenic mitochondrial variant …