The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …

An increasing number of women fail to achieve pregnancy due to either failed fertilization or
embryo arrest during preimplantation development. This often results from decreased oocyte …

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization
(IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays …

Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …

Initially perceived simply as an ATP producer, mitochondria also participate in a wide range
of other cellular functions. Mitochondrial communication with the nucleus, as well as …

In most animal species female germ cells are the source of mitochondrial genome for the
whole body of individuals. As a source of mitochondrial DNA for future generations the …

The mitochondrial genome contributes key proteins to the electron-transfer chain, which
through oxidative phosphorylation, generates the vast majority of cellular ATP. This …

James M. Cummins published" The Role of Maternal Mitochondria during Oogenesis,
Fertilization and Embryogenesis" 30 January 2002 in the journal Reproductive BioMedicine …

The mitochondrial genome passes from one generation to the next by way of the egg's
cytoplasm, so ordinarily an individual's mitochondrial DNA (mtDNA) is entirely derived from …

Mitochondrial disease can lead to clinical abnormalities in any organ system. Both inherited
and spontaneous disorders are known. The spontaneous forms can occur as a …