Mitochondrial DNA (mtDNA) plays a crucial role in the development of a competent oocyte.
Indeed, mtDNA alterations may predispose to chromosome nondisjunction, resulting in …

Maternal inheritance of mitochondrial DNA has long been regarded as a major paradox in
developmental biology. While some confusion may still persist in popular science, research …

BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

One of the most critical issues to be solved in reproductive medicine is the treatment of
patients with multiple failures of assisted reproductive treatment caused by low-quality …

Mitochondria are highly dynamic organelles of bacterial origin in eukaryotic cells. These
play a central role in metabolism and adenosine triphosphate (ATP) synthesis and in the …

BACKGROUND: Mitochondrial biogenesis and bioenergetics play an important role in
oocyte maturation and embryo development. We have investigated the relationship between …

Abstract BACKGROUND Mitochondrial DNA (mtDNA) encodes key proteins associated with
the process of oxidative phosphorylation. Defects to mtDNA cause severe disease …

Oocyte mitochondria are increased in number, smaller, and rounder in appearance than
mitochondria in somatic cells. Moreover, mitochondrial numbers and activity are narrowly …

Mitochondria transfer techniques were first designed to prevent the transmission of diseases
due to mutations in mtDNA, as these organelles are exclusively transmitted to the offspring …

Mitochondria undergo a myriad of changes during pre-implantation embryo development,
including shifts in activity levels and mitochondrial DNA (mtDNA) replication. However, how …