Is it possible to develop a “universal” influenza virus vaccine? Potential target antigens and critical aspects for a universal influenza vaccine

F Krammer, A García-Sastre… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Influenza viruses cause seasonal epidemics as well as pandemics and are a significant
concern for human health. Current influenza virus vaccines show efficacy when they are …

Optimizing the impact of low-efficacy influenza vaccines

P Sah, J Medlock, MC Fitzpatrick… - Proceedings of the …, 2018 - National Acad Sciences
The efficacy of influenza vaccines varies from one year to the next, with efficacy during the
2017–2018 season anticipated to be lower than usual. However, the impact of low-efficacy …

[引用][C] Inactivated influenza vaccines

CB Bridges, JM Katz, RA Levandowski, NJ Cox - Vaccines, 2008 - Elsevier

Towards universal influenza vaccines?

A Osterhaus, R Fouchier… - … Transactions of the …, 2011 - royalsocietypublishing.org
Vaccination is the most cost-effective way to reduce the considerable disease burden of
seasonal influenza. Although seasonal influenza vaccines are effective, their performance in …

Challenges of making effective influenza vaccines

S Gouma, EM Anderson… - Annual review of virology, 2020 - annualreviews.org
Seasonal influenza vaccines prevent influenza-related illnesses, hospitalizations, and
deaths. However, these vaccines are not as effective as other viral vaccines, and there is …

Vaccine approaches conferring cross-protection against influenza viruses

SV Vemula, EE Sayedahmed, S Sambhara… - Expert review of …, 2017 - Taylor & Francis
Introduction: Annual vaccination is one of the most efficient and cost-effective strategies to
prevent and control influenza epidemics. Most of the currently available influenza vaccines …

Immunity to influenza: the challenges of protecting an aging population

JM Katz, J Plowden, M Renshaw-Hoelscher, X Lu… - Immunologic …, 2004 - Springer
Influenz a viruses cause annual epidemics and occasional pandemics of acute respiratory
disease. Improved vaccines that can overcome the decline in immune function with aging …

Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines

RJ Cox, KA Brokstad, PL Ogra - Scandinavian journal of …, 2004 - Wiley Online Library
Influenza virus is a globally important respiratory pathogen which causes a high degree of
morbidity and mortality annually. The virus is continuously undergoing antigenic change and …

Mechanisms of broad cross-protection provided by influenza virus infection and their application to vaccines

S Tamura, T Tanimoto, T Kurata - Japanese journal of infectious …, 2005 - jstage.jst.go.jp
Mice recovered from influenza A virus infection have been shown to be cross-protected
against challenge infection with either drift viruses within a subtype (subtype-specific …

Inactivated and adjuvanted influenza vaccines

G Del Giudice, R Rappuoli - Influenza Pathogenesis and Control-Volume II, 2014 - Springer
Inactivated influenza vaccines are produced every year to fight against the seasonal
epidemics of influenza. Despite the nonoptimal coverage, even in subjects at risk like the …