Challenges in estimating influenza vaccine effectiveness

KEC Ainslie, M Haber, WA Orenstein - Expert review of vaccines, 2019 - Taylor & Francis
Introduction: Influenza vaccination is regarded as the most effective way to prevent influenza
infection. Due to the rapid genetic changes that influenza viruses undergo, seasonal …

Immune responses after live attenuated influenza vaccination

KGI Mohn, I Smith, H Sjursen… - Human vaccines & …, 2018 - Taylor & Francis
ABSTRACT Since 2003 (US) and 2012 (Europe) the live attenuated influenza vaccine
(LAIV) has been used as an alternative to the traditional inactivated influenza vaccines (IIV) …

Strategies in recommending influenza vaccination in Europe and US

C Rizzo, G Rezza, W Ricciardi - Human vaccines & …, 2018 - Taylor & Francis
There is potential for influenza vaccine programmes to make a substantial impact on the
disease burden. The World Health Organization (WHO) has identified young children …

The nature of immune responses to influenza vaccination in high-risk populations

KB Wiggins, MA Smith, S Schultz-Cherry - Viruses, 2021 - mdpi.com
The current pandemic has brought a renewed appreciation for the critical importance of
vaccines for the promotion of both individual and public health. Influenza vaccines have …

[HTML][HTML] Chasing seasonal influenza—the need for a universal influenza vaccine

CI Paules, SG Sullivan, K Subbarao… - New England Journal …, 2018 - Mass Medical Soc
Chasing Seasonal Influenza As we prepare for a potentially severe influenza season, we
must consider whether our current vaccines can be improved and whether longer-term …

[HTML][HTML] Who and when to vaccinate against influenza

P Buchy, S Badur - International Journal of Infectious Diseases, 2020 - Elsevier
Known since Hippocrates and of continuing public health importance, influenza remains a
major cause of morbidity and mortality worldwide, and large segments of the human …

[HTML][HTML] Cell-mediated protection in influenza infection

PG Thomas, R Keating, DJ Hulse-Post… - Emerging infectious …, 2006 - ncbi.nlm.nih.gov
Current vaccine strategies against influenza focus on generating robust antibody responses.
Because of the high degree of antigenic drift among circulating influenza strains over the …

Burden, effectiveness and safety of influenza vaccines in elderly, paediatric and pregnant populations

SG Sullivan, OH Price… - Therapeutic advances in …, 2019 - journals.sagepub.com
Vaccination is the most practical means available for preventing influenza. Influenza
vaccines require frequent updates to keep pace with antigenic drift of the virus, and the …

A synthetic influenza virus vaccine induces a cellular immune response that correlates with reduction in symptomatology and virus shedding in a randomized phase Ib …

O Pleguezuelos, S Robinson… - Clinical and Vaccine …, 2015 - Am Soc Microbiol
Current influenza vaccines elicit primarily antibody-based immunity. They require yearly
revaccination and cannot be manufactured until the identification of the circulating viral …

[HTML][HTML] Current and next generation influenza vaccines: Formulation and production strategies

PC Soema, R Kompier, JP Amorij… - European Journal of …, 2015 - Elsevier
Vaccination is the most effective method to prevent influenza infection. However, current
influenza vaccines have several limitations. Relatively long production times, limited vaccine …