The potentiality of mifepristone as an abortifacient and contraceptive drug along with its
pharmacokinetic parameters is reviewed. Mifepristone or RU486 acts as antagonist to …

Progesterone is one of the first nuclear receptor hormones to be described functionally and
subsequently approached as a drug target. Because progesterone (1) affects both …

Daily administration of progesterone (P) antagonists to women inhibits ovulation and
disrupts endometrial function. In this double-blind randomized trial, we have explored the …

Because of recent concerns about the long-term risks of estrogen replacement therapy in
postmenopausual women, there is growing interest in a group of compounds known as …

Asoprisnil is a novel selective progesterone receptor modulator that exhibits partial agonist
and antagonist activities in animals and humans. It demonstrates a high degree of …

Selective oestrogen receptor modulators (SERMs) are structurally diverse non-steroidal
compounds that bind to oestrogen receptors and produce oestrogen agonist effects in some …

Objective To assess the efficacy of various steroidal and nonsteroidal add-back regimes in
ameliorating hypoestrogenic side effects of long-term GnRH agonist (GnRH-a) therapy in …

Progesterone receptor modulators (PRMs) have been used for contraceptive research, as
well as for treatment of fibroids, endometriosis and heavy or irregular menstrual bleeding …

Exhibiting a strong affinity to the progesterone and the glucocorticoid receptors, mifepristone
exert competitive antagonism to these hormones both in in vitro and in animal experiments …