Asoprisnil is a novel selective steroid receptor modulator that shows unique
pharmacodynamic effects in animal models and humans. Asoprisnil, its major metabolite …

Progesterone is the natural progestagen produced by the corpus luteum during the luteal
phase. It is absorbed when administered orally, but is greater than 90% metabolized during …

The objective of this paper is to review the published and unpublished knowledge of the
effect of selective estrogen receptor modulators on reproductive tissues other than …

STUDY QUESTION Does the novel progesterone receptor (PR) modulator BAY 1002670,
based on its preclinical pharmacological profile, offer a potential novel treatment option for …

0002 Progesterone is a naturally occurring steroid which is the main Steroid Secreted by
Women during their repro ductive years. This Steroid has been Studied extensively and has …

A new approach for the treatment of breast cancer could be the use of progesterone
antagonists. These compounds were originally developed for the inhibition of progesterone …

Hormone receptors and, specifically, estrogen receptors were described about four decades
ago. For estrogens, there are two receptors, estrogen receptor alpha (ERalpha) and …

The safety of progestogens as a class has come under increased scrutiny after the
publication of data from the Women's Health Initiative trial, particularly with respect to breast …

Objective: To create an evidence-based position statement regarding the role of
progestogen in postmenopausal hormone therapy (estrogen plus a progestogen, or EPT) for …

Menopause brings about changes in the health of a postmenopausal woman that may have
a major impact in her life. Until recently, estrogens in various formulations and combinations …