Striatal adenosine–cannabinoid receptor interactions in rats over‐expressing adenosine A2A receptors

V Chiodi, A Ferrante, L Ferraro… - Journal of …, 2016 - Wiley Online Library
Abstract Adenosine A2A receptors (A2 AR s) and cannabinoid CB 1 receptors (CB 1Rs) are
highly expressed in the striatum, where they functionally interact and form A2A/CB 1 …

Dissecting striatal adenosine‐cannabinoid receptor interactions. New clues from rats over‐expressing adenosine A2A receptors

S Ferré, AM Sebastião - Journal of neurochemistry, 2016 - Wiley Online Library
This Editorial highlights a study by Chiodi et al.() showing that the effects mediated by
cannabinoid CB1 receptor (CB1R) activation in the striatum are significantly reduced in rats …

Pre‐synaptic adenosine A2A receptors control cannabinoid CB1 receptor‐mediated inhibition of striatal glutamatergic neurotransmission

A Martire, MT Tebano, V Chiodi… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 116, 273–280. Abstract An interaction between adenosine A2A
receptors (A2ARs) and cannabinoid CB1 receptors (CB1Rs) has been consistently reported …

Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum

MT Tebano, A Martire, V Chiodi… - Journal of …, 2009 - Wiley Online Library
Abstract Adenosine A2A, cannabinoid CB1 and metabotropic glutamate 5 (mGlu5) receptors
are all highly expressed in the striatum. The aim of the present work was to investigate …

Adenosine A2A–cannabinoid CB1 receptor interaction: An integrative mechanism in striatal glutamatergic neurotransmission

MT Tebano, A Martire, P Popoli - Brain research, 2012 - Elsevier
The striatum is a subcortical area involved in sensorimotor, cognitive and emotional
processes. Adenosine A2A receptors (A2ARs) are highly expressed in the striatum, and their …

Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors

AF Hoffman, N Laaris, M Kawamura… - Journal of …, 2010 - Soc Neuroscience
Marijuana is a widely used drug that impairs memory through interaction between its
psychoactive constituent, Δ-9-tetrahydrocannabinol (Δ9-THC), and CB1 receptors (CB1Rs) …

Singular location and signaling profile of adenosine A2A-cannabinoid CB1 receptor heteromers in the dorsal striatum

E Moreno, A Chiarlone, M Medrano… - …, 2018 - nature.com
The dorsal striatum is a key node for many neurobiological processes such as motor activity,
cognitive functions, and affective processes. The proper functioning of striatal neurons relies …

Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist

Z Justinová, S Ferré, GH Redhi, P Mascia… - Addiction …, 2011 - Wiley Online Library
Several recent studies suggest functional and molecular interactions between striatal
adenosine A2A and cannabinoid CB1 receptors. Here, we demonstrate that A2A receptors …

Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor‐mediated inhibition of corticostriatal glutamatergic transmission

SG Ferreira, FQ Gonçalves, JM Marques… - British Journal of …, 2015 - Wiley Online Library
Background and Purpose Both cannabinoid CB 1 and adenosine A2A receptors (CB1
receptors and A2A receptors) control synaptic transmission at corticostriatal synapses, with …

Adenosine–cannabinoid receptor interactions. Implications for striatal function

S Ferré, C Lluís, Z Justinova, C Quiroz… - British journal of …, 2010 - Wiley Online Library
Adenosine and endocannabinoids are very ubiquitous non‐classical neurotransmitters that
exert a modulatory role on the transmission of other more 'classical'neurotransmitters. In this …