Protein crowding in lipid bilayers gives rise to non-Gaussian anomalous lateral diffusion of phospholipids and proteins

JH Jeon, M Javanainen, H Martinez-Seara, R Metzler… - Physical Review X, 2016 - APS
Biomembranes are exceptionally crowded with proteins with typical protein-to-lipid ratios
being around 1∶ 50− 1∶ 100. Protein crowding has a decisive role in lateral membrane …

Anomalous and normal diffusion of proteins and lipids in crowded lipid membranes

M Javanainen, H Hammaren, L Monticelli… - Faraday …, 2013 - pubs.rsc.org
Lateral diffusion plays a crucial role in numerous processes that take place in cell
membranes, yet it is quite poorly understood in native membranes characterized by, eg …

[HTML][HTML] Non-Brownian diffusion in lipid membranes: Experiments and simulations

R Metzler, JH Jeon, AG Cherstvy - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
The dynamics of constituents and the surface response of cellular membranes—also in
connection to the binding of various particles and macromolecules to the membrane—are …

Reduced lateral mobility of lipids and proteins in crowded membranes

JE Goose, MSP Sansom - PLoS computational biology, 2013 - journals.plos.org
Coarse-grained molecular dynamics simulations of the E. coli outer membrane proteins
FhuA, LamB, NanC, OmpA and OmpF in a POPE/POPG (3∶ 1) bilayer were performed to …

Diffusion of integral membrane proteins in protein-rich membranes

M Javanainen, H Martinez-Seara… - The journal of …, 2017 - ACS Publications
The lateral diffusion of embedded proteins along lipid membranes in protein-poor conditions
has been successfully described in terms of the Saffman–Delbrück (SD) model, which …

Development of anomalous diffusion among crowding proteins

MR Horton, F Höfling, JO Rädler, T Franosch - Soft Matter, 2010 - pubs.rsc.org
In cell membranes, proteins and lipids diffuse in a highly crowded and heterogeneous
landscape, where aggregates and dense domains of proteins or lipids obstruct the path of …

[HTML][HTML] Effects of protein crowding on membrane systems

G Guigas, M Weiss - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2016 - Elsevier
Cellular membranes are typically decorated with a plethora of embedded and adsorbed
macromolecules, eg proteins, that participate in numerous vital processes. With typical …

Anomalous diffusion of phospholipids and cholesterols in a lipid bilayer and its origins

JH Jeon, HMS Monne, M Javanainen, R Metzler - Physical review letters, 2012 - APS
Combining extensive molecular dynamics simulations of lipid bilayer systems of varying
chemical compositions with single-trajectory analyses, we systematically elucidate the …

Mechanisms underlying anomalous diffusion in the plasma membrane

D Krapf - Current topics in membranes, 2015 - Elsevier
The plasma membrane is a complex fluid where lipids and proteins undergo diffusive motion
critical to biochemical reactions. Through quantitative imaging analyses such as single …

Concerted diffusion of lipids in raft-like membranes

T Apajalahti, P Niemelä, PN Govindan… - Faraday …, 2010 - pubs.rsc.org
Currently, there is no comprehensive model for the dynamics of cellular membranes. The
understanding of even the basic dynamic processes, such as lateral diffusion of lipids, is still …