An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins

S O'Regan, E Traiffort, M Ruat, N Cha… - Proceedings of the …, 2000 - National Acad Sciences
Choline is an important metabolite in all cells due to the major contribution of
phosphatidylcholine to the production of membranes, but it takes on an added role in …

Distribution of the putative vesicular transporter for acetylcholine in the rat central nervous system

A Roghani, A Shirzadi, LL Butcher, RH Edwards - Neuroscience, 1997 - Elsevier
In order to develop another selective marker for cholinergic cell bodies and fibres, we have
raised a highly specific polyclonal antibody against a peptide derived from the C-terminus of …

Cytosolic choline acetyltransferase binds specifically to cholinergic plasma membrane of rat brain synaptosomes to generate membrane-bound enzyme

P Gabrielle, M Jeana, EC Lorenza - Neurochemical research, 2003 - Springer
Uncovering the way membrane-bound choline acetyltransferase (ChAT) interacts with
membranes and with which membrane in cholinergic neurons may help in understanding its …

The high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice

MH Bazalakova, RD Blakely - Neurotransmitter transporters, 2006 - Springer
In cholinergic neurons, the presynaptic choline transporter (CHT) mediates high-affinity
choline uptake (HACU) as the rate-limiting step in acetylcholine (ACh) synthesis. It has …

Vesicular localization and activity-dependent trafficking of presynaptic choline transporters

SM Ferguson, V Savchenko… - Journal of …, 2003 - Soc Neuroscience
Presynaptic synthesis of acetylcholine (ACh) requires a steady supply of choline, acquired
by a plasma membrane, hemicholinium-3-sensitive (HC-3) choline transporter (CHT). A …

Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia

MJ Lecomte, S De Gois, A Guerci, P Ravassard… - Molecular and Cellular …, 2005 - Elsevier
Previous studies revealed that leukemia inhibitory factor (LIF) and retinoic acid (RA) induce
a noradrenergic to cholinergic switch in cultured sympathetic neurons of superior cervical …

The “ins” and “outs” of the high‐affinity choline transporter CHT1

FM Ribeiro, SAG Black, VF Prado… - Journal of …, 2006 - Wiley Online Library
Maintenance of acetylcholine (ACh) synthesis depends on the activity of the high‐affinity
choline transporter (CHT1), which is responsible for the reuptake of choline from the …

Expression of the high-affinity choline transporter, CHT1, in the rat trachea

U Pfeil, KS Lips, L Eberling, V Grau… - American journal of …, 2003 - atsjournals.org
The rate limiting step in neuronal acetylcholine (ACh) synthesis is the uptake of choline by
the high-affinity choline transporter (CHT1). Here, we investigated the distribution of CHT1 in …

Primary structure and functional expression of a choline transporter expressed in the rat nervous system

W Mayser, P Schloss, H Betz - FEBS letters, 1992 - Wiley Online Library
Synthesis of the neurotransmitter acetylcholine in cholinergic nerve terminals is regulated by
a sodium‐driven high‐affinity choline uptake system in the plasma membrane. We have …

Vesicular acetylcholine transporter (VAChT): a cellular marker in rat retinal development

P Koulen - Neuroreport, 1997 - journals.lww.com
A polyclonal goat antiserum against the C-terminal end of the rat vesicular acetylcholine
transporter (VAChT) was used to examine the postnatal expression of this protein in the rat …