NAD+ deficiency and mitochondrial dysfunction in granulosa cells of women with polycystic ovary syndrome

Y Wang, Q Yang, H Wang, J Zhu, L Cong… - Biology of …, 2021 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a prevalent heterogeneous endocrine disorder
characterized by ovulation dysfunction, androgen excess, ovarian polycystic changes …

Oxidative stress and mitochondrial dysfunction of granulosa cells in polycystic ovarian syndrome

Y Gao, Y Zou, G Wu, L Zheng - Frontiers in Medicine, 2023 - frontiersin.org
Polycystic ovarian syndrome (PCOS) is one of the leading causes of anovulatory infertility in
women, affecting 5%–15% of women of reproductive age worldwide. The clinical …

Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with polycystic ovary syndrome

Q Lai, W Xiang, Q Li, H Zhang, Y Li, G Zhu, C Xiong… - Frontiers of …, 2018 - Springer
The increased levels of intracellular reactive oxygen species (ROS) in granulosa cells (GCs)
may affect the pregnancy results in women with polycystic ovary syndrome (PCOS). In this …

Mitochondrial dysfunction and chronic inflammation in polycystic ovary syndrome

SA Dabravolski, NG Nikiforov, AH Eid… - International journal of …, 2021 - mdpi.com
Polycystic ovarian syndrome (PCOS) is the most common endocrine–metabolic disorder
affecting a vast population worldwide; it is linked with anovulation, mitochondrial …

Androgen excess induced mitochondrial abnormality in ovarian granulosa cells in a rat model of polycystic ovary syndrome

L Song, J Yu, D Zhang, X Li, L Chen, Z Cai… - Frontiers in …, 2022 - frontiersin.org
Background Androgen excess could profoundly lead to follicular dysplasia or atresia, and
finally result in polycystic ovary syndrome (PCOS); however, the exact mechanism remains …

Essential role of granulosa cell glucose and lipid metabolism on oocytes and the potential metabolic imbalance in polycystic ovary syndrome

CH Zhang, XY Liu, J Wang - International journal of molecular sciences, 2023 - mdpi.com
Granulosa cells are crucial for the establishment and maintenance of bidirectional
communication among oocytes. Various intercellular material exchange modes, including …

[HTML][HTML] Effect of vitamin D3 on mitochondrial biogenesis in granulosa cells derived from polycystic ovary syndrome

Z Safaei, S Bakhshalizadeh… - … Journal of Fertility & …, 2020 - ncbi.nlm.nih.gov
Background Polycystic ovary syndrome (PCOS) is an endocrine disorder diagnosed by
anovulation hyperandro-genism. Hyperandrogenism increases apoptosis, which will …

Distress response in granulosa cells of women affected by PCOS with or without insulin resistance

M Cozzolino, S Herraiz, Y Cakiroglu… - Endocrine, 2023 - Springer
Purpose In this study, we investigated whether metabolic dysfunction in women with
Polycystic ovarian syndrome (PCOS) induces granulosa cell (GC) stress and activates in the …

Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome

X Jiang, H Tai, X Xiao, S Zhang, S Cui, S Qi… - Frontiers in …, 2022 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a universal endocrine and metabolic disorder
prevalent in reproductive aged women. PCOS is often accompanied with insulin resistance …

Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3

Q Zhang, J Ren, F Wang, M Pan, L Cui, M Li… - Free Radical Biology and …, 2022 - Elsevier
Mitochondrial function and glucose metabolism play important roles in bidirectional
signaling between granulosa cells (GCs) and oocytes. However, the factors associated with …