Release and intercellular transfer of cell surface CD81 via microparticles

B Fritzsching, B Schwer, J Kartenbeck… - The Journal of …, 2002 - journals.aai.org
The human tetraspan molecule CD81 is a coreceptor in B and T cell activation and a
candidate receptor for hepatitis C virus infection. We examined the surface expression of …

Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic hepatitis C …

NL Yonkers, S Sieg, B Rodriguez… - Journal of Infectious …, 2011 - academic.oup.com
Background. Chronic hepatitis C virus (HCV) infection is characterized by reduced numbers
of functional HCV-specific T cells. In addition, chronically HCV-infected individuals have …

Liver tissue expression of CD80 and CD95 antigens in chronic hepatitis C: relationship with biological and histological disease activities.

G Fiore, G Piazzolla, V Galetta, L Caccetta, O Schiraldi… - Microbios, 1999 - europepmc.org
The well known discrepancy between cytotoxic T lymphocyte (CTL) infiltration in the liver
and disease biological activity, as assessed by alanine aminotransferase (ALT) levels …

Coligation of the hepatitis C virus receptor CD81 with CD28 primes naive T lymphocytes to acquire type 2 effector function

A Serra, S Nuti, S Tavarini, C Sammicheli… - The Journal of …, 2008 - journals.aai.org
Costimuli provide supplementary signals required by naive T cells to become fully activated
upon Ag encounter. Tetraspanins are a large family of transmembrane proteins that can …

Is CD81 the key to hepatitis C virus entry?

CM Rice - Hepatology, 1999 - journals.lww.com
Chronic hepatitis C virus (HCV) infection occurs in about 3 percent of the world's population
and is a major cause of liver disease. HCV infection is also associated with …

Autoantibodies to CD69 in patients with chronic hepatitis type C: a candidate marker for predicting the response to interferon therapy

N Okamoto, H Yotsuyanagi, S Ooka, T Matsui… - Intervirology, 2003 - karger.com
Objective: To understand the autoimmunity associated with chronic hepatitis C (CHC), we
investigated autoantibodies (autoAbs) to CD69. Methods: With this aim, we tested the …

Comparison of Envelope 2 CD81 binding regions in PBMC‐derived versus serum‐derived hepatitis C virus isolates: higher conservation of CD81 region 2 in PBMC …

MW Welker, C Welsch, D Ochs… - Journal of Viral …, 2011 - Wiley Online Library
The aim of the present study was to investigate the variability of hepatitis C virus (HCV)
CD81 binding regions (CD81‐1/2) in peripheral blood mononuclear cells (PBMC)‐derived …

Serum soluble CD14 in Egyptian patients with chronic hepatitis C: its relationship to disease progression and response to treatment

E Medhat, H Salama, H Fouad… - Journal of Interferon & …, 2015 - liebertpub.com
Hepatitis C virus (HCV) is a major public health problem. Soluble CD14 (sCD14) level was
shown to be associated with HCV infection. In this study, we aimed to investigate the …

CD49b, a Major Marker of Regulatory T‐Cells Type 1, Predicts the Response to Antiviral Therapy of Recurrent Hepatitis C after Liver Transplantation

S Fabien, M Olivier, G Khaldoun… - BioMed Research …, 2014 - Wiley Online Library
The TRANSPEG study was a prospective study to assess the efficacy of antiviral therapy in
patients with a recurrent hepatitis C virus (HCV) after liver transplantation. The influence of …

Lack of full CD8 functional restoration after antiviral treatment for acute and chronic hepatitis C virus infection

G Missale, M Pilli, A Zerbini, A Penna, L Ravanetti… - Gut, 2012 - gut.bmj.com
Background Hepatitis C virus (HCV) persistence is associated with impaired CD8 functions.
Whether functional restoration of CD8 T cells chronically exposed to antigen can be …