Lack of full CD8 functional restoration after antiviral treatment for acute and chronic hepatitis C virus infection
G Missale, M Pilli, A Zerbini, A Penna, L Ravanetti… - Gut, 2012 - gut.bmj.com
Background Hepatitis C virus (HCV) persistence is associated with impaired CD8 functions.
Whether functional restoration of CD8 T cells chronically exposed to antigen can be …
Whether functional restoration of CD8 T cells chronically exposed to antigen can be …
Novel function of CD81 in controlling hepatitis C virus replication
YY Zhang, BH Zhang, K Ishii, TJ Liang - Journal of virology, 2010 - Am Soc Microbiol
The mechanisms of hepatitis C virus (HCV) replication remain poorly understood, and the
cellular factors required for HCV replication are yet to be completely defined. CD81 is known …
cellular factors required for HCV replication are yet to be completely defined. CD81 is known …
Soluble CD26/30 levels before and after treatment with interferon-alpha and ribavirin combination therapy in a pediatric hepatitis C patient.
YR Liao, CP Yen, CC Lin, LS Fu, CC Chiu… - … Wei Mian yu gan ran za …, 2004 - europepmc.org
Chronic hepatitis C virus (HCV) infection frequently leads to end-stage liver diseases and
extrahepatic complications. Combination therapy with interferon-alpha (IFN-alpha) and …
extrahepatic complications. Combination therapy with interferon-alpha (IFN-alpha) and …
[PDF][PDF] Anti‐CD81 antibodies can prevent a hepatitis C virus infection in vivo
P Meuleman, J Hesselgesser, M Paulson… - …, 2008 - Wiley Online Library
The viral life cycle of the hepatitis C virus (HCV) has been studied mainly using different in
vitro cell culture models. Studies using pseudoviral particles (HCVpp) and more recently cell …
vitro cell culture models. Studies using pseudoviral particles (HCVpp) and more recently cell …
Expression of human CD81 in transgenic mice does not confer susceptibility to hepatitis C virus infection
F Masciopinto, G Freer, VL Burgio, S Levy… - Virology, 2002 - Elsevier
We previously demonstrated that hepatitis C virus (HCV) binds to human CD81 through the
E2 glycoprotein. Therefore, expression of the human CD81 molecule in transgenic mice was …
E2 glycoprotein. Therefore, expression of the human CD81 molecule in transgenic mice was …
[HTML][HTML] A Potential Inhibitory Profile of Liver CD68+ Cells during HCV Infection as Observed by an Increased CD80 and PD-L1 but Not CD86 Expression
EA Said, I Al-Reesi, M Al-Riyami, K Al-Naamani… - PloS one, 2016 - journals.plos.org
Aim The lack of potent innate immune responses during HCV infection might lead to a delay
in initiating adaptive immune responses. Kupffer cells (KCs) and liver-infiltrating monocytes …
in initiating adaptive immune responses. Kupffer cells (KCs) and liver-infiltrating monocytes …
Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent manner
We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H
and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor for …
and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor for …
[HTML][HTML] CD81 engineered with endocytotic signals mediates HCV cell entry: implications for receptor usage by HCV in vivo
YJ Tan, SP Lim, P Ng, PY Goh, SG Lim, YH Tan… - Virology, 2003 - Elsevier
Although CD81 has been shown to bind HCV E2 protein, its role as a receptor for HCV
remains controversial. In this study, we constructed two CD81 chimeras by linking the …
remains controversial. In this study, we constructed two CD81 chimeras by linking the …
Structure-function analysis of hepatitis C virus envelope-CD81 binding
Hepatitis C virus (HCV) is a major human pathogen causing chronic liver disease. We have
recently found that the large extracellular loop (LEL) of human CD81 binds HCV. This …
recently found that the large extracellular loop (LEL) of human CD81 binds HCV. This …
Impact of single nucleotide polymorphisms in the essential HCV entry factor CD81 on HCV infectivity and neutralization
M Deest, S Westhaus, E Steinmann, MP Manns… - Antiviral research, 2014 - Elsevier
End stage liver disease caused by chronic infection with the hepatitis C virus (HCV) is a
leading indication for liver transplantation, yet outcomes are poor since the liver graft is …
leading indication for liver transplantation, yet outcomes are poor since the liver graft is …