Background Hepatitis C virus (HCV) persistence is associated with impaired CD8 functions.
Whether functional restoration of CD8 T cells chronically exposed to antigen can be …

The mechanisms of hepatitis C virus (HCV) replication remain poorly understood, and the
cellular factors required for HCV replication are yet to be completely defined. CD81 is known …

Chronic hepatitis C virus (HCV) infection frequently leads to end-stage liver diseases and
extrahepatic complications. Combination therapy with interferon-alpha (IFN-alpha) and …

The viral life cycle of the hepatitis C virus (HCV) has been studied mainly using different in
vitro cell culture models. Studies using pseudoviral particles (HCVpp) and more recently cell …

We previously demonstrated that hepatitis C virus (HCV) binds to human CD81 through the
E2 glycoprotein. Therefore, expression of the human CD81 molecule in transgenic mice was …

Aim The lack of potent innate immune responses during HCV infection might lead to a delay
in initiating adaptive immune responses. Kupffer cells (KCs) and liver-infiltrating monocytes …

We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H
and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor for …

Although CD81 has been shown to bind HCV E2 protein, its role as a receptor for HCV
remains controversial. In this study, we constructed two CD81 chimeras by linking the …

Hepatitis C virus (HCV) is a major human pathogen causing chronic liver disease. We have
recently found that the large extracellular loop (LEL) of human CD81 binds HCV. This …

End stage liver disease caused by chronic infection with the hepatitis C virus (HCV) is a
leading indication for liver transplantation, yet outcomes are poor since the liver graft is …