Bacterial genomes are functionally organized and compactly folded into a structure referred
to as bacterial chromatin or the nucleoid. An important role in genome folding is attributed to …

The bacterial genome is folded into a compact structure called the nucleoid. Considerable
compaction of the DNA molecule is required in order to reduce its volume below that of the …

Bacterial chromosomes are folded to compact DNA and facilitate cellular processes.
Studying model bacteria has revealed aspects of chromosome folding that are applicable to …

Since the nucleoid was isolated from bacteria in the 1970s, two fundamental questions
emerged and are still in the spotlight: how bacteria organize their chromosomes to fit inside …

Chromosomes in all domains of life are well-defined structural entities with complex
hierarchical organization. The regulation of this hierarchical organization and its functional …

The genomic DNA of all organisms across the three kingdoms of life needs to be compacted
and functionally organized. Key players in these processes are DNA supercoiling …

The proper function of the genome largely depends on the higher order architecture of the
chromosome. Our previous application of nanotechnology to the questions regarding the …

Recent advances in bacterial cell biology have revealed unanticipated structural and
functional complexity, reminiscent of eukaryotic cells. Particular progress has been made in …

The effective volume occupied by the genomes of all forms of life far exceeds that of the cells
in which they are contained. Therefore, all organisms have developed mechanisms for …

Highlights•Bacterial chromosomes are highly organized spatially and temporally.•Recent
technical advances dramatically enhance studies of chromosome biology.•Microscopy …