Perfusion, hypoxia and nucleoside uptake during ganciclovir therapy were determined in a
murine HSV-1 TK-expressing tumour model (KBALB-STK). HSV-1 TK mRNA transcription in …

We are developing procedures to repeatedly and noninvasively ¡ magethe expression of
transplanted reporter genes in living ani mals and in patients, using PET. We have …

In vivo transduction of the herpes simplex virus type-1 thymidine kinase (HSV-1 TK) gene
and subsequent administration of antiviral drugs such as ganciclovir has emerged as a …

Radiolabelled ganciclovir analogues have shown promise as imaging agents to detect
herpes simplex virus thymidine kinase (HSV tk) expression. This study evaluated the use of …

Assessments of herpes simplex virus 1 thymidine kinase (HSV-tk)/ganciclovir (GCV)
treatment response, early in the course of therapy, are important in the evaluation and …

The ability to monitor tumor responses during prodrug activation gene therapy and other
anticancer gene therapies is critical for their translation into clinical practice. Previously, we …

Methods: Morris hepatoma cells were transfected with a retroviral vector bearing the HSVtk
gene, and different clones were estab lished by selection with the neomycin analog G418 …

We report a series of studies that assess the feasibility and sensitivity of imaging of herpes
virus type one thymidine kinase (HSV1-tk) gene transfer and expression with [124I]-5-iodo …

One type of gene therapy of tumors, gene-directed enzyme-prodrug therapy (GDEPT), holds
considerable promise, although practical considerations limit its clinical applicability. These …

Using a rat C6 brain tumor model, we studied the antitumor effects of Herpes simplex virus
type 1 thymidine kinase (HSV-tk) gene transfer followed by ganciclovir treatment. C6 glioma …