Abstract The DNA topoisomerase I (topI) inhibitor camptothecin (CPT), stabilizes so-called
cleavable complexes which consist of topI covalently attached to 3'OH ends of DNA nicks …

Malignant cell proliferation and accumulation depends on the balance between the rates of
cell production and cell death. Recent evidence indicates that apoptosis is important in the …

Camptothecin (CAM) and cisplatin (cis-diamminedichloroplatinum (II), cis-Pt) were used as
inducers of apoptosis in the mouse leukemic L1210 cells. Relatively high concentrations of …

The role of wild-type human p53 protein in enhancing camptothecin cytotoxicity was
examined by infecting human prostate PC3 cells with adenovirus expressing human wild …

Camptothecin (CPT) derivatives are topoisomerase I (top1) inhibitors recently introduced as
clinical agents. To explore the role of p53 in CPT-induced cytotoxicity, we examined CPT …

We have previously shown that loss of p53 function in A2780 human ovarian
adenocarcinoma cells confers increased clonogenic resistance to several DNA-damaging …

Anticancer inhibitors of topoisomerase I (TOP1, EC 5.99. 1.2) cause the reversible
stabilization of the TOP1-DNA covalent complex (cleavable complex). The cleavable …

Recently, natural product DNA topoisomerase I inhibitors 10-hydroxycamptothecin (HCPT)
and camptothecin (CPT) have been shown to have therapeutic effects in both in vitro and in …

In this study we characterize the connections between p53-dependent G1 cell cycle arrest,
transcriptional activation of the protein and the increase of its intracellular steady-state …

Uncontrolled cell proliferation is the most characteristic feature of cancer and the cell cycle,
in particular the phase of DNA replication, is the target of a large majority of successful …