[HTML][HTML] A multilocus genetic risk score for obesity: Association with BMI and metabolic alterations in a cohort with severe obesity
SJM Sag, S Mueller, S Wallner, C Strack, U Hubauer… - Medicine, 2023 - journals.lww.com
Genome wide association studies have identified numerous single nucleotide
polymorphisms (SNPs) associated with obesity, yet effect sizes of individual SNPs are small …
polymorphisms (SNPs) associated with obesity, yet effect sizes of individual SNPs are small …
Dissecting the clinical relevance of polygenic risk score for obesity—a cross-sectional, longitudinal analysis
EK Choe, M Shivakumar, SM Lee, A Verma… - International Journal of …, 2022 - nature.com
Background Obesity is a global pandemic disease whose prevalence is increasing
worldwide. The clinical relevance of a polygenic risk score (PRS) for obesity has not been …
worldwide. The clinical relevance of a polygenic risk score (PRS) for obesity has not been …
Penetrance of polygenic obesity susceptibility loci across the body mass index distribution: an update on scaling effects
ABSTRACT A growing number of single nucleotide polymorphisms (SNPs) have been
associated with body mass index (BMI) and obesity, but whether the effect of these obesity …
associated with body mass index (BMI) and obesity, but whether the effect of these obesity …
Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity
Obesity is a major public health problem with strong genetic determination. Multiple genetic
variants have been implicated for obesity by conducting genome-wide association (GWA) …
variants have been implicated for obesity by conducting genome-wide association (GWA) …
Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity
S Hägg, A Ganna, SW Van Der Laan… - Human molecular …, 2015 - academic.oup.com
To date, genome-wide association studies (GWASs) have identified> 100 loci with single
variants associated with body mass index (BMI). This approach may miss loci with high …
variants associated with body mass index (BMI). This approach may miss loci with high …
Penetrance of polygenic obesity susceptibility loci across the body mass index distribution
A growing number of single-nucleotide polymorphisms (SNPs) have been associated with
body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility …
body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility …
Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
Objective: Several genome–wide association studies (GWAS) have demonstrated that
common genetic variants contribute to obesity. However, studies of this complex trait have …
common genetic variants contribute to obesity. However, studies of this complex trait have …
Identification of three genetic variants as novel susceptibility loci for body mass index in a Japanese population
Y Yasukochi, J Sakuma, I Takeuchi… - Physiological …, 2018 - journals.physiology.org
Recent genome-wide association studies have identified various obesity or metabolic
syndrome (MetS) susceptibility loci. However, most studies were conducted in a cross …
syndrome (MetS) susceptibility loci. However, most studies were conducted in a cross …
The challenge of stratifying obesity: attempts in the Quebec family study
J de Toro-Martín, F Guénard, C Bouchard… - Frontiers in …, 2019 - frontiersin.org
Background and aims: Obesity is a major health problem worldwide. Given the
heterogeneous obesity phenotype, an optimal obesity stratification would improve clinical …
heterogeneous obesity phenotype, an optimal obesity stratification would improve clinical …
Developments in obesity genetics in the era of genome-wide association studies
Obesity is an important factor contributing to the global burden of morbidity and mortality. By
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology …
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology …