Fungal infections are often difficult to treat due to the inherent similarities between fungal
and animal cells and the resulting host toxicity from many antifungal compounds …

We identified and attempted to disrupt the Cryptococcus neoformans homoserine and/or
threonine biosynthetic genes encoding aspartate kinase (HOM3), homoserine kinase …

The human fungal pathogen Cryptococcus neoformans relies on a complex signaling
network for the adaptation and survival at the host temperature. Protein phosphatase …

Insertional mutagenesis was applied to Cryptococcus neoformans to identify genes
associated with virulence attributes. Using biolistic transformation, we generated 4,300 …

The use of amphotericin B (AmB) in conjunction with 5-fluorocytosine (5-FC) is known to be
the optimal therapy for treating cryptococcosis, but the mechanism by which 5-FC synergizes …

Cryptococcus neoformans is an important fungal pathogen of man. The incidence of
cryptococcal disease has increased dramatically in patients immunocompromised because …

ABSTRACT A library of more than 4,500 signature-tagged insertion mutants of the human
pathogenic fungus Cryptococcus neoformans was generated, and a subset was screened in …

The fungus Cryptococcus neoformans is the causative agent of cryptococcosis, a disease
that is uniformly lethal unless treated with antifungal drugs, yet current regimens are …

The opportunistic human fungal pathogen Cryptococcus neoformans has tremendous
impact on global health, causing 181,000 deaths annually. Current treatment options are …

The spliceosome, a large complex containing five conserved small ribonucleoprotein
particles (snRNPs) U1, U2, U4, U5 and U6, plays important roles in precursor messenger …