[HTML][HTML] Unraveling antibiotic resistance mechanisms in Mycobacterium abscessus: the potential role of efflux pumps

SE Mudde, JA Schildkraut, NC Ammerman… - Journal of Global …, 2022 - Elsevier
Objectives Mycobacterium abscessus is an opportunistic respiratory pathogen in patients
with underlying lung disease. It is infamously known for its low treatment success rates …

The Contribution of Efflux Pumps in Mycobacterium abscessus Complex Resistance to Clarithromycin

JS Vianna, D Machado, IB Ramis, FP Silva… - Antibiotics, 2019 - mdpi.com
The basis of drug resistance in Mycobacterium abscessus is still poorly understood.
Nevertheless, as seen in other microorganisms, the efflux of antimicrobials may also play a …

Exploring antibiotic resistance mechanisms in Mycobacterium abscessus for enhanced therapeutic approaches

TQ Nguyen, BE Heo, S Jeon, A Ash, H Lee… - Frontiers in …, 2024 - frontiersin.org
Mycobacterium abscessus, a leading cause of severe lung infections in
immunocompromised individuals, poses significant challenges for current therapeutic …

The TetR family transcription factor MAB_2299c regulates the expression of two distinct MmpS-MmpL efflux pumps involved in cross-resistance to clofazimine and …

AV Gutiérrez, M Richard… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Mycobacterium abscessus is a human pathogen responsible for severe respiratory
infections, particularly in patients with underlying lung disorders. Notorious for being highly …

Targeting bedaquiline mycobacterial efflux pump to potentially enhance therapy in Mycobacterium abscessus

A Martin, Y Bouyakoub, K Soumillion… - The International …, 2020 - journals.lww.com
Background: Mycobacterium abscessus is notorious for being intrinsically resistant to most
antibiotics. Antibiotic efflux is one of the mechanisms used by M. abscessus to pump out …

Efflux Pumps Contribute to Intrinsic Clarithromycin Resistance in Clinical, Mycobacterium abscessus Isolates

Q Guo, J Chen, S Zhang, Y Zou, Y Zhang… - Infection and drug …, 2020 - Taylor & Francis
Purpose The emergence of clarithromycin resistance is a challenge in treating
Mycobacterium abscessus infections. Known mechanisms that contribute to intrinsic …

The Role of Antibiotic-Target-Modifying and Antibiotic-Modifying Enzymes in Mycobacterium abscessus Drug Resistance

S Luthra, A Rominski, P Sander - Frontiers in microbiology, 2018 - frontiersin.org
The incidence and prevalence of non-tuberculous mycobacterial (NTM) infections have
been increasing worldwide and lately led to an emerging public health problem. Among …

Efflux pump effects on levofloxacin resistance in Mycobacterium abscessus

T Teng, S Chen, F Huo, J Jia, L Zhao… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Mycobacterium abscessus (M. abscessus) inherently displays resistance to most antibiotics,
with the underlying drug resistance mechanisms remaining largely unexplored. Efflux pump …

[HTML][HTML] Mechanistic and structural insights into the unique TetR-dependent regulation of a drug efflux pump in Mycobacterium abscessus

M Richard, AV Gutiérrez, AJ Viljoen, E Ghigo… - Frontiers in …, 2018 - frontiersin.org
Mycobacterium abscessus is an emerging human pathogen causing severe pulmonary
infections and is refractory to standard antibiotherapy, yet few drug resistance mechanisms …

RNA sequencing elucidates drug-specific mechanisms of antibiotic tolerance and resistance in Mycobacterium abscessus

JA Schildkraut, JPM Coolen, S Burbaud… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Mycobacterium abscessus is an opportunistic pathogen notorious for its resistance to most
classes of antibiotics and low cure rates. M. abscessus carries an array of mostly unexplored …