Erectile dysfunction resulting from pelvic surgery is associated with changes in cavernosal gene expression indicative of cavernous nerve injury

G Villegas, MT Tar, KP Davies - Andrologia, 2022 - Wiley Online Library
Pelvic surgery, even without direct cavernous nerve injury, carries a high risk of post‐
operative erectile dysfunction. The present studies were aimed at identifying molecular …

A mouse model of cavernous nerve injury-induced erectile dysfunction: functional and morphological characterization of the corpus cavernosum

HR Jin, YG Chung, WJ Kim, LW Zhang… - The Journal of …, 2010 - academic.oup.com
Introduction With the advent of genetically engineered mice, it seems important to develop a
mouse model of cavernous nerve injury (CNI). Aim To establish a mouse model of CNI …

M1 macrophages are predominantly recruited to the major pelvic ganglion of the rat following cavernous nerve injury

H Matsui, NA Sopko, JL Hannan… - The journal of sexual …, 2017 - academic.oup.com
Introduction Neurogenic erectile dysfunction is a common sequela of radical prostatectomy.
The etiology involves injury to the autonomic cavernous nerves, which arise from the major …

[HTML][HTML] Gene expression profile comparison in the penile tissue of diabetes and cavernous nerve injury-induced erectile dysfunction rat model

SC Kam, SH Lee, JH Jeon, I So… - … and clinical urology, 2016 - synapse.koreamed.org
Purpose To investigate the effects of cavernous nerve injury (CNI) on gene expression
profiles in the cavernosal tissue of a CNI-induced erectile dysfunction (ED) model and to …

Increased level of tumor necrosis factor-alpha (TNF-α) leads to downregulation of nitrergic neurons following bilateral cavernous nerve injury and modulates penile …

H Matsui, NA Sopko, JD Campbell, X Liu… - The journal of sexual …, 2021 - academic.oup.com
Background Erectile dysfunction (ED) after injury to peripheral cavernous nerve (CN) is
partly a result of inflammation in pelvic ganglia, suggesting that ED may be prevented by …

Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury

G Calenda, TD Strong, CP Pavlovich… - BJU …, 2012 - Wiley Online Library
What's known on the subject? and What does the study add? With the present study, we
aimed to provide a global picture of the molecular processes that are activated by CN injury …

The development of a rat model of erectile dysfunction after radical prostatectomy: preliminary findings

O Kaufmann, J Claro, J Cury, E Andrade… - BJU …, 2008 - Wiley Online Library
OBJECTIVE To develop a rat model of erectile dysfunction (ED) after cavernous nerve injury.
MATERIALS AND METHODS Given the great similarity between the anatomical structure of …

Cavernous nerve injury using rodent animal models

O Canguven, A Burnett - The journal of sexual medicine, 2008 - academic.oup.com
Introduction With the advance of the “nerve sparing” technique in radical pelvic surgeries,
medically unaided rates of normal erectile function following surgery have improved. Precise …

Pathway analysis of microarray data from corpora cavernosal tissue of patients with a prostatectomy or Peyronie disease in comparison with a cavernous nerve …

T Searl, S Ohlander, KT McVary… - The journal of sexual …, 2023 - academic.oup.com
Introduction Patients with a prostatectomy are at high risk of developing erectile dysfunction
(ED) that is refractory to phosphodiesterase type 5 inhibitors. The cavernous nerve (CN) is …

Increased expression of nestin in the major pelvic ganglion following cavernous nerve injury

O Kutlu, AE Ross, EM Schaeffer, C Gratzke… - International journal of …, 2012 - nature.com
In an effort to identify neuronal repair mechanisms of the major pelvic ganglion (MPG), we
evaluated changes in the expression of nestin, an intermediate filament protein and neural …