Clinical studies that use observational databases to evaluate the effects of medical products
have become commonplace. Such studies begin by selecting a particular database, a …

Background Large health care utilization databases are frequently used to analyze
unintended effects of prescription drugs and biologics. Confounders that require detailed …

Background: Nonexperimental studies of drug effects in large automated databases can
provide timely assessment of real-life drug use, but are prone to confounding by variables …

Recent clinical trials demonstrating that hormone replacement therapy (HRT) does not
prevent coronary heart disease in women have again raised doubts concerning …

Pharmacoepidemiology is the study of the utilization and effects of drugs in clinical and
population settings, and the outcomes of drug therapy. The growing trend of recording …

Abstract Purpose of Review Risk is an important parameter to describe the occurrence of
health outcomes over time. However, many outcomes of interest in healthcare settings, such …

The rapid entry of health care into the electronic age has led to a proliferation of large data
repositories of healthrelated information. Such data are collected for administrative and …

Recent technological developments in recording health care delivery have led to major
research opportunities for epidemiologists and others. There has been a dramatic increase …

The scientific community and decision‐makers are increasingly concerned about
transparency and reproducibility of epidemiologic studies using longitudinal healthcare …

Many studies of population health, clinical epidemiology, and health services can be
supported by a population-based research registry. Such a registry accurately defines the …