Currently, approximately 67% of children diagnosed with cancer can be expected to survive
more than 5 years. Among the most significant late effects of cancer therapy is the …

BACKGROUND Previous studies have shown that children who are treated for soft tissue
sarcoma (STS) are at increased risk for developing second cancers. However, the risk for …

Background. The occurrence of second malignant neoplasms (SMNs) in successfully treated
pediatric patients with cancer has been an area of increasing concern because survival of …

BACKGROUND Survivors of childhood malignancies have an increased risk of developing
second malignant neoplasms (SMN) due to their prior treatment and/or genetic …

BACKGROUND: To examine the incidence, characteristics, and outcomes for second
malignancies following the diagnosis of a primary solid tumor in pediatric patients …

This study was conducted to determine the outcome of patients who develop a second
neoplasm after radiotherapy (RT) for a childhood solid tumor. From 1956 to 1998, 429 …

Nine patients who had an osteosarcoma that had developed as a second malignant
neoplasm in a previously irradiated site were managed at a major center for the treatment of …

There is a clear association between multimodal therapy for bone tumors and the
development of skeletal complications; however, this has not been addressed in children …

PURPOSE This study was performed to determine the incidence and risk factors involved in
the development of a second malignant neoplasm (SMN) after treatment of primary …

As the cure rate for childhood malignancies increases, the number of patients at risk for
development of second malignancies also increases. Due to the potentially long remaining …