Abstract Objective Sirtuin 1 (SirT1) has been implicated in the regulation of human cartilage
homeostasis and chondrocyte survival. Exposing human osteoarthritic (OA) chondrocytes to …

Objective We and others previously demonstrated that sirtuin 1 (SIRT‐1) regulates apoptosis
and cartilage‐specific gene expression in human chondrocytes and mouse models. This …

Objective Previous work has established that the deacetylase sirtuin-1 (SIRT1) is cleaved by
cathepsin B in chondrocytes subjected to proinflammatory stress, yielding a stable but …

Abstract Objective The protein deacetylase SirT1 inhibits apoptosis in a variety of cell
systems by distinct mechanisms, yet its role in chondrocyte death has not been explored. We …

Osteoarthritis (OA) is mainly characterized by the progressive destruction of articular
cartilage. Mounting studies have revealed that disruption of extracellular matrix (ECM) …

Objective The aim of this study is to investigate the role of Sirtuin1 (Sirt1) in the regulation of
autophagy for human osteoarthritis (OA) chondrocytes. Design All cartilage samples were …

Objective SIRT1 is known to inhibit apoptosis and to promote survival of various types of
cells. However, the roles of SIRT1 in apoptosis of human chondrocytes have never been …

Sirtuins have been involved in the osteoarthritis (OA) process. However, the functions of
SIRT4 in the degeneration of human chondrocytes and OA are not fully understood. This …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation
and destruction of synovial joints. The function of sirtuin (SIRT) 1 in RA is inconclusive. In …

Abstract Objective The protein deacetylase SirT1 positively regulates cartilage‐specific gene
expression, while the proinflammatory cytokine tumor necrosis factor α (TNFα) negatively …