BACKGROUND: Systemic infections commonly cause sickness symptoms including
psychomotor retardation. Inflammatory cytokines released during the innate immune …

Cognitive impairments reported across psychiatric conditions (ie, major depressive disorder,
bipolar disorder, schizophrenia, and posttraumatic stress disorder) strongly impair the …

Psychological stress promotes the development and recurrence of anxiety and depressive
behavioral symptoms. Basic and clinical research indicates that stress exposure can …

Repeated social defeat (RSD) is a murine stressor that recapitulates key physiological,
immunological, and behavioral alterations observed in humans exposed to chronic …

BACKGROUND: Inflammation is associated with psychological, emotional, and behavioral
disturbance, known as sickness behavior. Inflammatory cytokines are implicated in …

Task-based fMRI has been used to study the effects of experimental inflammation on the
human brain, but it remains unknown whether intrinsic connectivity in the brain at rest …

Findings from numerous laboratories and across neuroimaging modalities have consistently
shown that exogenous administration of cytokines or inflammatory stimuli that induce …

BACKGROUND: Chronic neurodegeneration results in microglial activation, but the
contribution of inflammation to the progress of neurodegeneration remains unclear. We have …

Systemic inflammation impacts on the brain and gives rise to behavioral changes, often
referred to as 'sickness behavior'. These symptoms are thought to be mainly mediated by pro …

Background Inflammation impairs cognitive performance and is implicated in the
progression of neurodegenerative disorders. Rodent studies demonstrated key roles for …