This perspective on Jin et al.(beginning on page 910 in this issue of the journal) discusses
the importance of estrogen signaling in colorectal carcinogenesis, with a focus on estrogen …

Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …

Worldwide, colorectal cancer has a higher incidence rate in men than in women, suggesting
a protective role for sex hormones in the development of the disease. Preclinical data …

Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use
them to optimize the health benefits and avoid adverse effects is a major challenge …

Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate
intracellular signaling cascades that have important consequences for cellular behavior …

Colorectal cancer (CRC) is the second cause of cancer-related death in both sexes
worldwide. As pre-menopausal women are less likely to develop CRC compared to age …

Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …

Background Estrogen receptor β (ERβ) is a potential tumor-suppressor gene in colorectal
cancer (CRC). This hypothesis is supported by clinical and laboratory observations. Aim In …

Several studies suggest estrogen to be protective against the development of colon cancer.
Estrogen receptor β (ERβ) is the predominant estrogen receptor expressed in colorectal …

The role of oestrogen in oncogenesis has been examined extensively, especially in the
context of breast cancer, and receptor modulators are an integral part of targeted treatment …