AIMS: The SEISMIC study was an open-label, prospective, randomised study to assess the
safety and feasibility of percutaneous myoblast implantation in heart failure patients with …

The seminal experiments showing that cells transplanted in infarcted hearts could effect
myocardial tissue repair have provided the proof of concept that cell therapy might be an …

Autologous skeletal myoblast transplantation might improve postinfarction ventricular
function, but graft viability and differentiation (ie, proof of concept) has not been shown. A 72 …

Background—Multiple cell types are being proposed for cardiac repair, but side-by-side
comparisons are lacking. We tested the hypothesis that intracardiac transplantation of …

Background—Autologous skeletal myoblast (SM) transplantation improves function of
infarcted myocardium, but pretransplantation cultures remain a complex process. This study …

Background—Myocardial infarction (MI) promotes deleterious remodeling of the
myocardium, resulting in ventricular dilation and pump dysfunction. We examined whether …

OBJECTIVES: Cellular cardiomyoplasty with isolated skeletal myoblasts and bone marrow
mononuclear cells is an encouraging therapeutic strategy for heart failure. We investigated …

Background Skeletal myoblast transplantation is promising for the treatment of end-stage
heart failure. Direct intramyocardial injection is useful for local cell delivery but may not be …

Myocardial regeneration can be induced with the implantation of a variety of myogenic and
angiogenic cell types. More than 150 patients have been treated with cellular …

Congestive heart failure, which is most commonly caused by myocardial infarction, is the
most frequent cause of hospitalization in the United States in patients over the age of 65 …