BACKGROUND: Hypothermia during ischemia has been shown to reduce myocardial
reperfusion injury. We sought to establish the cardioprotective effect of very mild total-body …

Abstract Mild hypothermia (32–35° C) salvages ischemic myocardium and reduces infarct
size in hearts undergoing ischemia/reperfusion. It is clear that a cardioprotective effect is …

BACKGROUND: Mild hypothermia (< 4° C) improves myocardial salvage after infarct
reperfusion in animals and in early clinical studies. In this experiment the effect of mild …

Background In experimentally induced myocardial infarction, mild hypothermia (33–35° C) is
beneficial if applied prior to ischemia or reperfusion. Hypothermia, when applied after …

The cardioprotective effect of therapeutic hypothermia (32–34° C) has been well
demonstrated in animal models of acute myocardial infarction. Beyond infarct size reduction …

The present study describes a method for rapidly cooling the whole body via its blood pool
and tests whether cooling instituted after ischemia has begun can sill limit infarction. We also …

Objective: Previously we observed that a large reduction in infarct size was attained by
cooling the risk region of the heart, either before or early after the onset of a 30-min coronary …

Reducing the heart's temperature by 2–5° C is a potent cardioprotective treatment in animal
models of coronary artery occlusion. The anti-infarct benefit depends upon the target …

Previously, we observed that reducing myocardial temperature in the risk region before
coronary artery occlusion caused a profound reduction in infarct size. It is unknown whether …

Two previous clinical trials investigating hypothermia as an adjunct therapy for myocardial
infarction have failed. Recently a pilot study has demonstrated a significant reduction in …