From a holistic point of view, aging results from the cumulative erosion of the various
systems. Among these, the immune system is interconnected to the rest as immune cells are …

Immunosenescence, describing alterations, including decline of immune responses with
age, is comprised of inappropriate elevations, decreases, and dysregulated immune …

Age is the most important risk factor for tumorigenesis. More than 60% of new cancers and
more than 70% of cancer deaths occur in elderly subjects> 65 years. The immune system …

In response to persistent DNA damage, induction into cell senescence promotes an
immunogenic program which facilitates immune clearance of these damaged cells. Under …

The immune system, interacting intimately with the cancer cells in a tumor, may combat or
favor cancer development and progression, or both. One of the most important risk factors for …

Highlights•There is a general signal transduction alteration in immune cells with human
aging.•The most important changes occur at the proximal signaling of TCR.•Not only the …

The innate immune system is composed of a network of cells including neutrophils, NK and
NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions …

The past decade has seen an explosion in research focusing on innate immunity. Through a
wide range of mechanisms including phagocytosis, intracellular killing and activation of …

Immunosenescence refers to the inability of an aging immune system to produce an
appropriate and effective response to challenge. This immune dysfunction may manifest as …

The aging process is associated with chronic low-grade inflammation in both humans and
rodents, commonly called inflammaging. At the same time, there is a gradual decline in the …