Immune aging is best known for its immune defects that increase susceptibility to infections
and reduce adaptive immune responses to vaccination. In parallel, the aged immune system …

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …

Publisher Summary This chapter discusses the basis for age-dependent changes in immune
function. Aging converts a fit, mature adult into an increasingly infirm one. The mechanisms …

The increasing ratio of ageing population poses new challenges to healthcare systems. The
elderly frequently suffer from severe infections. Vaccination could protect them against …

Age is a major risk factor for many cancers. Although this is usually viewed in the context of
the cell biology, we argue here that age-associated changes to immunity may also …

Acquired immune function shows recognizable changes over time with organismal aging.
These changes include T-cell dysfunction, which may underlie diminished resistance to …

As humans live longer, a central concern is to find ways to maintain their health as they age.
Immunity declines during ageing, as shown by the increased susceptibility to infection by …

The aging immune system (immunosenescence) has been implicated with increased
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …

Can the immune system be reactivated continuously throughout the lifetime of an organism
or is there a finite point at which repeated antigenic challenge leads to the loss of …