The janus head of T cell aging–autoimmunity and immunodeficiency
JJ Goronzy, G Li, Z Yang, CM Weyand - Frontiers in immunology, 2013 - frontiersin.org
Immune aging is best known for its immune defects that increase susceptibility to infections
and reduce adaptive immune responses to vaccination. In parallel, the aged immune system …
and reduce adaptive immune responses to vaccination. In parallel, the aged immune system …
Mechanisms underlying T cell ageing
JJ Goronzy, CM Weyand - Nature Reviews Immunology, 2019 - nature.com
T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …
Immunosenescence: what does it mean to health outcomes in older adults?
JE McElhaney, RB Effros - Current opinion in immunology, 2009 - Elsevier
The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …
Aging and immune function
RA Miller - International review of cytology, 1991 - Elsevier
Publisher Summary This chapter discusses the basis for age-dependent changes in immune
function. Aging converts a fit, mature adult into an increasingly infirm one. The mechanisms …
function. Aging converts a fit, mature adult into an increasingly infirm one. The mechanisms …
Factors that may impact on immunosenescence: an appraisal
J Ongrádi, V Kövesdi - Immunity & ageing, 2010 - Springer
The increasing ratio of ageing population poses new challenges to healthcare systems. The
elderly frequently suffer from severe infections. Vaccination could protect them against …
elderly frequently suffer from severe infections. Vaccination could protect them against …
Immunosenescence and cancer
Age is a major risk factor for many cancers. Although this is usually viewed in the context of
the cell biology, we argue here that age-associated changes to immunity may also …
the cell biology, we argue here that age-associated changes to immunity may also …
Physiology and pathology of T-cell aging
N Minato, M Hattori, Y Hamazaki - International immunology, 2020 - academic.oup.com
Acquired immune function shows recognizable changes over time with organismal aging.
These changes include T-cell dysfunction, which may underlie diminished resistance to …
These changes include T-cell dysfunction, which may underlie diminished resistance to …
Senescence of T lymphocytes: implications for enhancing human immunity
As humans live longer, a central concern is to find ways to maintain their health as they age.
Immunity declines during ageing, as shown by the increased susceptibility to infection by …
Immunity declines during ageing, as shown by the increased susceptibility to infection by …
The interplay between immunosenescence and age-related diseases
F Barbé-Tuana, G Funchal, CRR Schmitz… - Seminars in …, 2020 - Springer
The aging immune system (immunosenescence) has been implicated with increased
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …
Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
AN Akbar, SM Henson - Nature Reviews Immunology, 2011 - nature.com
Can the immune system be reactivated continuously throughout the lifetime of an organism
or is there a finite point at which repeated antigenic challenge leads to the loss of …
or is there a finite point at which repeated antigenic challenge leads to the loss of …