Aging is a natural physiological process that features various and variable challenges,
associated with loss of homeostasis within the organism, often leading to negative …

The study of immune dysfunction in the aged organism has much to contribute to our
understanding of the biology of aging. Since the decline in protective immune reactions with …

The functional competence of the immune system gradually declines with aging, a process
called immunosenescence. The age-related remodelling of the immune system affects both …

Infections, cancer and autoimmune diseases occur more frequently in the elderly, and
although many factors contribute to this, the age-related remodelling of the immune system …

Age is an important risk for autoimmunity, and many autoimmune diseases preferentially
occur in the second half of adulthood when immune competence has declined and thymic T …

The immune system undergoes age-associated changes known as immunosenescence,
resulting in increased susceptibility to infections, cancers and autoimmunity in the aged. The …

Immunosenescence is an age-associated decline of immunity involving multiorgan changes.
As the mean age of the population increases, an increase of diverse pathologies associated …

Aging of the immune system in humans and animals is characterized by a decline in both
adaptive and innate immune responses. Paradoxically, aging is also associated with a state …

Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …

The aging process is associated with a remodeling of the immune system involving chronic
low-grade inflammation and a gradual decline in the function of the immune system. These …