Immunosenescence influences many components of the immune system. Most importantly,
profound changes in T cell function are evident in older individuals. The impact of aging on …

Chronic low-grade inflammation is a common hallmark of the aging process and many age-
related diseases. There is substantial evidence that persistent inflammation is associated …

The interrelation of the processes of immunity and senescence now receives an
unprecedented emphasis during the COVID-19 pandemic, which brings to the fore the …

The world's population is aging, which brings about huge scientific challenges. Since the
biological process of aging is by far the greatest risk factor for most chronic diseases …

Immune functions decline as we age, while the incidence of cancer rises. The advent of
immune checkpoint blockade (ICB) has not only revolutionized cancer therapy, but also …

Aging-associated changes in the function of the immune system are referred to as senescent
immune remodeling (SIR). Here we review the current understanding on the cellular and …

Beyond midlife, the immune system shows aging features and its defensive capability
becomes impaired, by a process known as immunosenescence that involves many changes …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Immunological studies of aging and of patients with chronic immune-mediated diseases
document overlap of immune phenotypes. Here, the term 'immune remodeling'refers to …

The function of the immune system is to maintain body integrity by defending against
infections, cancers, autoimmune diseases and inflammation-related chronic diseases. The …