Effects of aging on T cell function
L Haynes, AC Maue - Current opinion in immunology, 2009 - Elsevier
Immunosenescence influences many components of the immune system. Most importantly,
profound changes in T cell function are evident in older individuals. The impact of aging on …
profound changes in T cell function are evident in older individuals. The impact of aging on …
Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases
A Salminen - Journal of molecular medicine, 2021 - Springer
Chronic low-grade inflammation is a common hallmark of the aging process and many age-
related diseases. There is substantial evidence that persistent inflammation is associated …
related diseases. There is substantial evidence that persistent inflammation is associated …
[HTML][HTML] Innate and adaptive immunity in aging and longevity: the foundation of resilience
The interrelation of the processes of immunity and senescence now receives an
unprecedented emphasis during the COVID-19 pandemic, which brings to the fore the …
unprecedented emphasis during the COVID-19 pandemic, which brings to the fore the …
Aging of the immune system: research challenges to enhance the health span of older adults
L Haynes - Frontiers in aging, 2020 - frontiersin.org
The world's population is aging, which brings about huge scientific challenges. Since the
biological process of aging is by far the greatest risk factor for most chronic diseases …
biological process of aging is by far the greatest risk factor for most chronic diseases …
Immune aging and immunotherapy in cancer
M Kaiser, MD Semeraro, M Herrmann… - International Journal of …, 2021 - mdpi.com
Immune functions decline as we age, while the incidence of cancer rises. The advent of
immune checkpoint blockade (ICB) has not only revolutionized cancer therapy, but also …
immune checkpoint blockade (ICB) has not only revolutionized cancer therapy, but also …
HSC aging and senescent immune remodeling
MD Denkinger, H Leins, R Schirmbeck, MC Florian… - Trends in …, 2015 - cell.com
Aging-associated changes in the function of the immune system are referred to as senescent
immune remodeling (SIR). Here we review the current understanding on the cellular and …
immune remodeling (SIR). Here we review the current understanding on the cellular and …
When aging reaches CD4+ T-cells: phenotypic and functional changes
MA Moro-García, R Alonso-Arias… - Frontiers in …, 2013 - frontiersin.org
Beyond midlife, the immune system shows aging features and its defensive capability
becomes impaired, by a process known as immunosenescence that involves many changes …
becomes impaired, by a process known as immunosenescence that involves many changes …
Immunosenescence and human vaccine immune responses
SN Crooke, IG Ovsyannikova, GA Poland… - Immunity & …, 2019 - Springer
The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …
“immunosenescence”—has been generally associated with an increased susceptibility to …
Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease
AN Vallejo - Trends in molecular medicine, 2007 - cell.com
Immunological studies of aging and of patients with chronic immune-mediated diseases
document overlap of immune phenotypes. Here, the term 'immune remodeling'refers to …
document overlap of immune phenotypes. Here, the term 'immune remodeling'refers to …
Dysregulation of T-cell function in the elderly: scientific basis and clinical implications
T Fulop, A Larbi, A Wikby, E Mocchegiani, K Hirokawa… - Drugs & aging, 2005 - Springer
The function of the immune system is to maintain body integrity by defending against
infections, cancers, autoimmune diseases and inflammation-related chronic diseases. The …
infections, cancers, autoimmune diseases and inflammation-related chronic diseases. The …