Encapsulated thrombolytic microspheres to prevent reocclusion after thrombolysis and triggered release microspheres to deliver therapeutic drugs

H Nguyen - 2015 - shareok.org
Cardiovascular diseases, including acute myocardial infarction, stroke, peripheral arterial
diseases, and pulmonary embolism, are the most common and growing cause of morbidity …

An In Vitro Thrombolysis Study Using a Mixture of Fast-Acting and Slower Release Microspheres

HX Nguyen, EA O'Rear - Pharmaceutical research, 2016 - Springer
Purpose To test the hypothesis that a mixture combining fast and slower release rate
microspheres can restore blood flow rapidly and prevent formation of another blockage in …

Biphasic release of protein from polyethylene glycol and polyethylene glycol/modified dextran microspheres

HX Nguyen, EA O'Rear - Journal of Biomedical Materials …, 2013 - Wiley Online Library
Dextrans show great promise for delivery of therapeutic agents. Dextran acetates (DAs)
were synthesized with increasing degrees of substitution (DA1< DA2< DA3) by the reaction …

Particles for Targeted Delivery and Uses in Managing Bleeding or Blood Clotting

WA Lam, C Hansen, Y Sakurai… - US Patent App. 18/343,932, 2023 - Google Patents
US20230330031A1 - Particles for Targeted Delivery and Uses in Managing Bleeding or Blood
Clotting - Google Patents US20230330031A1 - Particles for Targeted Delivery and Uses in …

[HTML][HTML] Bio-inspired microcapsule for targeted antithrombotic drug delivery

W Ye, N Wang, K Hu, L Zhang, A Liu, C Pan, T Gong… - RSC …, 2018 - pubs.rsc.org
Thrombosis or embolism is the leading cause of death and long-term adult disability
worldwide. To reduce the risk of thrombosis and hemorrhaging in patients, a facile and …

Reducing the Side Effects of Thrombolytic Agent by Regulating its Release Rate from Microcapsules

L Mukhametova, R Aisina, K Gerchkovich… - …, 2019 - thieme-connect.com
Methods: PEG microcapsules containing SK were prepared by the method of double
emulsification, using an ultrasonic device and polyvinyl alcohol as emulsifying agent. To …

Thrombolytic microspheres to dissolve vaso-occlusive clots

RCK Yen - US Patent App. 17/208,736, 2021 - Google Patents
A product, composition, suspension and/or method to treat subjects infected with respiratory
viruses, such as coronavirus, and in relieving hypoxic condition. A suspension of …

Drug delivery under cover of erythrocytes extends drug half-life: A thrombolytic targeting therapy utilizing microenvironment-responsive artificial polysaccharide …

L Shan, J Wang, H Tu, W Zhang, H Li, P Slezak… - Carbohydrate …, 2024 - Elsevier
The development of thrombolytic drug carriers capable of thrombus-targeting, prolonged
circulation time, intelligent responsive release, and the ability to inhibit thrombotic …

Modified dextran, heparin-based triggered release microspheres for cardiovascular delivery of therapeutic drugs using protamine as a stimulus

HX Nguyen, EA O'Rear - Journal of Microencapsulation, 2017 - Taylor & Francis
In this study, we describe the synthesis of an amine-modified acetalated dextran polymer,
which is combined with heparin (HP) as the basis for a novel controlled release system …

Particles for targeted delivery and uses in managing bleeding or blood clotting

WA Lam, C Hansen, Y Sakurai, A Lyon - US Patent 11,730,701, 2023 - Google Patents
This disclosure relates to microcapsule particles for targeted delivery of drugs. In certain
embodiments, the particles comprise polyelectrolyte polymers, eg, layers of anionic …