Background Acute lung injury (ALI) is a fatal disease in the absence of pharmacological
treatment. Oxidative stress and inflammation are closely related to ALI. Innate immune cells …

Development of localized inflammatory environments by M1 macrophages in the cardiac
infarction region exacerbates heart failure after myocardial infarction (MI). Therefore, the …

The efficacy of cardiac regenerative strategies for myocardial infarction (MI) treatment is
greatly limited by the cardiac microenvironment. The combination of reactive oxygen species …

Currently, single therapeutic strategy designed for only boosting anti-inflammatory response
or angiogenesis in treating myocardial infarction (MI) has met with limited success due to …

Background Pancreatic beta cell dysfunction and activated macrophage infiltration are early
features in type 1 diabetes pathogenesis. A tricarboxylic acid cycle metabolite that can …

Acute myocardial infarction (AMI) induces a sterile inflammatory response, leading to
cardiomyocyte damage and adverse cardiac remodeling. Interleukin-5 (IL-5) plays an …

Inflammatory response plays a critical role in myocardial infarction (MI) repair. The
neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation …

Protection of cardiomyocytes against oxidative stress is vital to alleviate myocardial
ischemia/reperfusion injury (MI/RI). However, antioxidative treatment is hampered by the …

An in-depth understanding of biomaterial cues to selectively polarize macrophages is
beneficial in the design of “immuno-informed” biomaterials that positively interact with the …

Itaconate has emerged as a critical immunoregulatory metabolite. Here, we examined the
therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the …