In this study, we have investigated the hypothesis that previously reported beneficial effect of
peripheral blood mononuclear cells cultured under angiogenic conditions on cardiovascular …

Background Exosomes derived from bone marrow mesenchymal stem cells (MSC-exo) have
been considered as a promising cell-free therapeutic strategy for ischemic heart disease …

Myocardial ischaemia is pathologically complicated; various changes in intracellular and
extracellular microenvironments make it essential to develop a smart drug system with …

Background: Myocardium irreversibly injured by ischemic stress must be efficiently repaired
to maintain tissue integrity and contractile performance. Macrophages play critical roles in …

Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

To diminish heart failure development after acute myocardial infarction (AMI), several
preclinical studies have focused on influencing the inflammatory processes in the healing …

Atherosclerosis is chronic inflammatory disease tightly related with defective efferocytosis of
apoptotic cells (ACs) in the plaques. The strategy of efferocytosis reactivation using …

Background: Inflammatory responses play a critical role in left ventricular remodeling after
myocardial infarction (MI). Tolerogenic dendritic cells (tDCs) can modulate immune …

Objectives: The aim of this study was to test whether silencing of the transcription factor
interferon regulatory factor 5 (IRF5) in cardiac macrophages improves infarct healing and …

Following acute myocardial ischemia reperfusion (MIR), macrophages infiltrate damaged
cardiac tissue and alter their polarization phenotype to respond to acute inflammation and …